Molecular disruption of hypothalamic nutrient sensing induces obesity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

Banting Lecture 2001

2002 • 1,445 citations

Obesity Wars

2004 • 1,119 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

2000 • 983 citations

Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

2001 • 880 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

Diabetes, Obesity, and the Brain

2005 • 840 citations

Obesity in the new millennium

2000 • 707 citations

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

2002 • 640 citations

Hypothalamic KATP channels control hepatic glucose production

2005 • 633 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

2003 • 523 citations

Hypothalamic sensing of fatty acids

2005 • 461 citations

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

2004 • 448 citations

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

2004 • 439 citations

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

2005 • 425 citations

Leptin selectively decreases visceral adiposity and enhances insulin action.

1997 • 349 citations

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

1987 • 335 citations

Hypothalamic malonyl-CoA as a mediator of feeding behavior

2003 • 262 citations

Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay.

1978 • 193 citations

Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.

1993 • 191 citations

Determination of short-chain acyl-coenzyme A esters by high-performance liquid chromatography

1986 • 54 citations