Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

2004 • 1,896 citations

The AMP‐Activated Protein Kinase

1997 • 1,313 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

Lipotoxic heart disease in obese rats: Implications for human obesity

2000 • 1,257 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

A novel mouse model of lipotoxic cardiomyopathy

2001 • 741 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.

1978 • 586 citations

Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging

2003 • 421 citations

Novel Form of Lipolysis Induced by Leptin

1999 • 362 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Liporegulation in Diet-induced Obesity

2001 • 265 citations

Rapid transformation of white adipocytes into fat-oxidizing machines

2004 • 231 citations

Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression

1998 • 211 citations

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

1996 • 186 citations

Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis

2002 • 179 citations

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

1998 • 102 citations