Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

2003 • 989 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease

2000 • 956 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

1996 • 794 citations

Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome

2003 • 672 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Pathophysiological role of leptin in obesity-related hypertension

2000 • 479 citations

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

2000 • 463 citations

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

1995 • 440 citations

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

1997 • 434 citations

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

1997 • 404 citations

AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise

2001 • 369 citations

Serum Adiponectin and Leptin Levels in Patients with Lipodystrophies

2002 • 365 citations

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

2004 • 299 citations

AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

2002 • 293 citations

Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes

2001 • 239 citations

Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome

2002 • 237 citations

Rapid transformation of white adipocytes into fat-oxidizing machines

2004 • 231 citations

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

1999 • 211 citations

Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system

1998 • 192 citations

Chronic Treatment With 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside Increases Insulin-Stimulated Glucose Uptake and GLUT4 Translocation in Rat Skeletal Muscles in a Fiber Type--Specific Manner

2001 • 190 citations

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

2004 • 182 citations

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

2004 • 172 citations

5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle

2004 • 159 citations

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

2002 • 146 citations

Possible involvement of the α1 isoform of 5′AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle

2004 • 138 citations

AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment

2003 • 130 citations

Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism

2002 • 118 citations

Mitochondrial Uncoupling Proteins in Energy Expenditure

2000 • 116 citations

Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin‐induced diabetic rats

2002 • 106 citations

Leptin directly alters lipid partitioning in skeletal muscle

1997 • 100 citations

AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females

2004 • 95 citations

Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.

1999 • 92 citations

Leptin as an adjunct of insulin therapy in insulin-deficient diabetes

2003 • 52 citations

Hyperleptinemia Precipitates Diet-Induced Obesity in Transgenic Mice Overexpressing Leptin

2003 • 47 citations

Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin

2001 • 27 citations