The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety
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References (126)
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 • 8,227 citations
Polyphenols: food sources and bioavailability
2004 • 7,472 citations
Neurogenesis in the adult human hippocampus
1998 • 6,181 citations
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
2003 • 4,175 citations
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
1999 • 3,805 citations
Dietary Intake and Bioavailability of Polyphenols
2000 • 3,564 citations
More hippocampal neurons in adult mice living in an enriched environment
1997 • 3,476 citations
The Neuroendocrinology of Stress: A Never Ending Story
2008 • 3,415 citations
The tail suspension test: A new method for screening antidepressants in mice
1985 • 3,300 citations
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
2000 • 3,047 citations
Mechanisms and Functional Implications of Adult Neurogenesis
2008 • 2,904 citations
Cytokines sing the blues: inflammation and the pathogenesis of depression
2005 • 2,801 citations
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
1995 • 2,090 citations
Vascular niche for adult hippocampal neurogenesis
2000 • 1,805 citations
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
2005 • 1,794 citations
Protective and Damaging Effects of Mediators of Stress: Elaborating and Testing the Concepts of Allostasis and Allostatic Load
1999 • 1,726 citations
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
1997 • 1,468 citations
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
1977 • 1,438 citations
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
1998 • 1,386 citations
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
2011 • 1,360 citations
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
1995 • 1,352 citations
For the Long Run
2004 • 1,289 citations
Neurogenesis in the Neocortex of Adult Primates
1999 • 1,268 citations
Adult hippocampal neurogenesis in depression
2007 • 1,170 citations
Brain foods: the effects of nutrients on brain function
2008 • 1,160 citations
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
2004 • 1,101 citations
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
2008 • 1,011 citations
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
2006 • 992 citations
Are New Neurons Formed in the Brains of Adult Mammals?
1962 • 930 citations
Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions
1966 • 904 citations
Stress and hippocampal neurogenesis
1999 • 799 citations
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment
2003 • 796 citations
Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways
1999 • 785 citations
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
1999 • 765 citations
Cytokine, Sickness Behavior, and Depression
2009 • 733 citations
Stress and adult neurogenesis
2006 • 685 citations
Vasopressinergic Control of Pituitary Adrenocorticotropin Secretion Comes of Age
1993 • 651 citations
Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
2006 • 631 citations
“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine
1978 • 604 citations
Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
2006 • 584 citations
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
2008 • 526 citations
Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal
2008 • 512 citations
Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone
2003 • 506 citations
Glucocorticoids, cytokines and brain abnormalities in depression
2010 • 501 citations
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
2002 • 449 citations
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression
1993 • 440 citations
Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor-κB Pathway
2007 • 427 citations
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
2011 • 413 citations
Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat
1997 • 409 citations
Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?
1995 • 391 citations
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
2008 • 383 citations
Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology
2008 • 370 citations
Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone‐dependent mechanism
2001 • 367 citations
Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training
2011 • 365 citations
Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus
2008 • 328 citations
Cytokines: abnormalities in major depression and implications for pharmacological treatment
2004 • 319 citations
Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats
2004 • 299 citations
The HPA and immune axes in stress: the involvement of the serotonergic system
2005 • 298 citations
Neuroinflammation: Modulation by flavonoids and mechanisms of action
2011 • 291 citations
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
2007 • 287 citations
Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge
2010 • 287 citations
Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease
2011 • 285 citations
Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
2006 • 282 citations
The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
2007 • 280 citations
Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition
2006 • 280 citations
Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
2007 • 272 citations
Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
2010 • 267 citations
Sex and seasonal changes in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles
1999 • 266 citations
Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects
2007 • 250 citations
The effects of curcumin on depressive-like behaviors in mice
2005 • 244 citations
The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
2011 • 231 citations
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
2002 • 229 citations
Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness
2003 • 222 citations
Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects
2009 • 213 citations
Signaling in adult neurogenesis
2010 • 209 citations
Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease
2008 • 205 citations
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
1999 • 204 citations
Effects of Cytokines on Glucocorticoid Receptor Expression And Function
1999 • 200 citations
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors
2007 • 187 citations
Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
2008 • 184 citations
Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system
2010 • 180 citations
Impact of diet on adult hippocampal neurogenesis
2009 • 174 citations
Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging
2006 • 167 citations
Polyphenols and Aging
2010 • 167 citations
Green tea polyphenols produce antidepressant-like effects in adult mice
2011 • 162 citations
Requirement of adult-born neurons for hippocampus-dependent learning
2011 • 162 citations
Inhibition of the NF‐κB transcriptional activity by protein kinase A
2002 • 155 citations
Anxiolytic properties of green tea polyphenol (−)-epigallocatechin gallate (EGCG)
2006 • 155 citations
Behavioral and genoprotective effects of Vaccinium berries intake in mice
2006 • 145 citations
Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
2008 • 138 citations
Voluntary exercise in C57 mice is anxiolytic across several measures of anxiety
2008 • 135 citations
Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice
2009 • 135 citations
Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases
2011 • 134 citations
The distribution of minerals and flavonoids in the tea plant (Camellia sinensis)
2001 • 127 citations
A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats
2007 • 123 citations
Stress, Metaplasticity, and Antidepressants
2002 • 121 citations
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress
2009 • 118 citations
Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress
2009 • 118 citations
Activin in the Brain Modulates Anxiety-Related Behavior and Adult Neurogenesis
2008 • 110 citations
Implications of the Functional Integration of Adult-Born Hippocampal Neurons in Anxiety-Depression Disorders
2010 • 100 citations
Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane).
1995 • 97 citations
Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B
2009 • 92 citations
A Diet Enriched in Polyphenols and Polyunsaturated Fatty Acids, LMN Diet, Induces Neurogenesis in the Subventricular Zone and Hippocampus of Adult Mouse Brain
2009 • 91 citations
Cocoa Procyanidins and Human Cytokine Transcription and Secretion
2000 • 88 citations
Fear learning transiently impairs hippocampal cell proliferation
2004 • 87 citations
Effects of Epigallocatechin-3-gallate on lead-induced oxidative damage
2008 • 85 citations
Chlorogenic Acid and Its Metabolitem-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells
2008 • 72 citations
Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival
2010 • 72 citations
High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome
2010 • 72 citations
Handbook of depression
1995 • 71 citations
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation
2008 • 70 citations
Evaluation of antidepressant like activity of curcumin and its combination with fluoxetine and imipramine: an acute and chronic study.
2011 • 68 citations
LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease
2011 • 67 citations
The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats
2008 • 66 citations
Effect of dietary tea polyphenols on growth performance and cell-mediated immune response of post-weaning piglets under oxidative stress
2010 • 62 citations
NT-020, a Natural Therapeutic Approach to Optimize Spatial Memory Performance and Increase Neural Progenitor Cell Proliferation and Decrease Inflammation in the Aged Rat
2010 • 62 citations
Chronic green tea consumption prevents age-related changes in rat hippocampal formation
2009 • 58 citations
Antidepressant-like effects of a cocoa polyphenolic extract in Wistar–Unilever rats
2008 • 53 citations
Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity
2010 • 50 citations
Differential Protection among Fractionated Blueberry Polyphenolic Families against DA-, Aβ42- and LPS-Induced Decrements in Ca2+ Buffering in Primary Hippocampal Cells
2010 • 48 citations
Differential Neuroprotective Activity of Two Different Grape Seed Extracts
2011 • 47 citations
Highly Oligomeric Procyanidins Ameliorate Experimental Autoimmune Encephalomyelitis via Suppression of Th1 Immunity
2006 • 46 citations
Effects of epigallocatechin-3-gallate on behavioral impairments induced by psychological stress in rats
2010 • 35 citations
Grape Seed Extract Acting on Astrocytes Reveals Neuronal Protection Against Oxidative Stress via Interleukin-6-mediated Mechanisms
2009 • 34 citations
Additions and Corrections to alpha(v) integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion.
1995 • 21 citations
Reversal of LPS‐induced immobility in mice by green tea polyphenols: possible COX‐2 mechanism
2004 • 21 citations