Polyphenols and Aging

Modes of resistance to anti-angiogenic therapy

2008 • 2,783 citations

Angiogenesis: an organizing principle for drug discovery?

2007 • 2,179 citations

Health effects of quercetin: From antioxidant to nutraceutical

2008 • 1,828 citations

Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

2004 • 1,375 citations

Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

2005 • 1,305 citations

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

2009 • 1,150 citations

Lifespan and reproduction in Drosophila : New insights from nutritional geometry

2008 • 968 citations

Targeting Multiple Signaling Pathways by Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate

2006 • 792 citations

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

2008 • 719 citations

Polyphenols in foods are more complex than often thought

2005 • 705 citations

Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets

2006 • 675 citations

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

2008 • 659 citations

Reactive oxygen species as universal constraints in life-history evolution

2009 • 638 citations

The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment

2008 • 566 citations

Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

2008 • 503 citations

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

2004 • 488 citations

How should we assess the effects of exposure to dietary polyphenols in vitro?

2004 • 488 citations

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

2009 • 451 citations

Sex-Specific Fitness Effects of Nutrient Intake on Reproduction and Lifespan

2008 • 440 citations

Nuclear Factor-κB Activation: From Bench to Bedside

2008 • 412 citations

Resveratrol: Its Biologic Targets and Functional Activity

2009 • 382 citations

Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

2003 • 369 citations

Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health

2007 • 359 citations

The “French paradox” and beyond: neuroprotective effects of polyphenols1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.

2002 • 325 citations

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

2007 • 315 citations

Resveratrol addiction: To die or not to die

2008 • 307 citations

The immune system and the impact of zinc during aging

2009 • 305 citations

Role for TNF in atherosclerosis? Lessons from autoimmune disease

2009 • 280 citations

Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration

2003 • 272 citations

Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APP_SwMice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

2004 • 264 citations

EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer

2007 • 264 citations

Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague‐Dawley rats

2008 • 239 citations

Molecular targets of tea polyphenols in the cardiovascular system

2006 • 239 citations

Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway

2004 • 230 citations

Therapeutic potential of resveratrol in Alzheimer's disease

2008 • 221 citations

Botanical Phenolics and Brain Health

2008 • 217 citations

Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

2008 • 214 citations

Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study

2009 • 214 citations

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

2009 • 207 citations

Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

2008 • 205 citations

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

2006 • 200 citations

Mechanisms and Effects of Green Tea on Cardiovascular Health

2008 • 189 citations

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

2008 • 178 citations

Protection against Nitric Oxide Toxicity by Tea

2000 • 177 citations

Epigallocatechin‐3‐gallate inhibits STAT‐1 activation and protects cardiac myocytes from ischemia/reperfusion‐ induced apoptosis

2004 • 171 citations

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

2005 • 156 citations

Resveratrol, at Concentrations Attainable with Moderate Wine Consumption, Stimulates Human Platelet Nitric Oxide Production3

2008 • 153 citations

Anti-inflammatory effect of resveratrol on TNF-α-induced MCP-1 expression in adipocytes

2008 • 144 citations

Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis

2003 • 136 citations

Metabolic Activation of Herbal and Dietary Constituents and Its Clinical and Toxicological Implications: An Update

2007 • 132 citations

Inhibition of UVB-Induced Skin Tumor Development by Drinking Green Tea Polyphenols Is Mediated Through DNA Repair and Subsequent Inhibition of Inflammation

2008 • 129 citations

Sirtuin activators

2009 • 129 citations

Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS

2006 • 126 citations

Nitric oxide‐mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen‐activated protein kinase

2003 • 125 citations

Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer Prevention

2008 • 125 citations

The scientific basis of caloric restriction leading to longer life

2009 • 121 citations

Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor‐α via the p38 mitogen‐activated protein kinase pathway

2009 • 116 citations

Diet and cardiovascular diseases.

2001 • 106 citations

Beneficial Effects of Resveratrol on Atherosclerosis

2008 • 105 citations

Role of oxidative stress and AT₁ receptors in cerebral vascular dysfunction with aging

2009 • 101 citations

Quercetin-mediated longevity in Caenorhabditis elegans: Is DAF-16 involved?

2008 • 100 citations

Risk Factors for Esophageal Cancer Development

2009 • 99 citations

Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

2009 • 99 citations

Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis

2007 • 98 citations

Metabolic benefits from Sirt1 and Sirt1 activators

2009 • 96 citations

Tea Polyphenols and Their Roles in Cancer Prevention and Chemotherapy

2008 • 95 citations

Specific Plasma Membrane Binding Sites for Polyphenols, Including Resveratrol, in the Rat Brain

2006 • 94 citations

Sirtuins: Novel targets for metabolic disease in drug development

2008 • 81 citations

Regulation of cell survival by resveratrol involves inhibition of NFκB‐regulated gene expression in prostate cancer cells

2009 • 78 citations

A Computational Model of Aging and Calcification in the Aortic Heart Valve

2009 • 75 citations

Distinct mechanisms underlie distinct polyphenol‐induced neuroprotection

2006 • 68 citations

eNOS Activation Induced by a Polyphenol-Rich Grape Skin Extract in Porcine Coronary Arteries

2009 • 68 citations

Relationships between cancer and aging: a multilevel approach

2009 • 67 citations

Suppression of NFκB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model

2008 • 67 citations

Suppressive Effects of Hydroxytyrosol on Oxidative Stress and Nuclear Factor-κB Activation in THP-1 Cells

2009 • 66 citations

Cortical α7 Nicotinic Acetylcholine Receptor and β-Amyloid Levels in Early Alzheimer Disease

2009 • 63 citations

Chronic Treatment with Red Wine Polyphenol Compounds Mediates Neuroprotection in a Rat Model of Ischemic Cerebral Stroke3

2008 • 61 citations

Protective effect of resveratrol in endotoxemia-induced acute phase response in rats

2008 • 59 citations

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells

2008 • 56 citations

EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression

2009 • 55 citations

The age distribution of cancer and a multi-stage theory of carcinogenosis

2004 • 55 citations

Mechanisms and Effects of Green Tea on Cardiovascular Health

2007 • 52 citations

EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase

2008 • 51 citations

Angiogenesis inhibitors in the treatment of cancer

2005 • 50 citations

Comparative Neuroprotective Properties of Stilbene and Catechin Analogs: Action Via a Plasma Membrane Receptor Site?

2009 • 50 citations

Inflammatory Cytokine Tumor Necrosis Factor α Confers Precancerous Phenotype in an Organoid Model of Normal Human Ovarian Surface Epithelial Cells

2009 • 50 citations

Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin

2007 • 49 citations

Epigallocatechin gallate can significantly decrease free oxygen radicals in the reperfusion injury in vivo

2003 • 45 citations

Preventive effect of (−)epigallocatechin-gallate (EGCG) on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats

2008 • 42 citations

Inhibitory Effect of (-)-Epigallocatechin and (-)-Epigallocatechin Gallate against Heregulin .BETA.1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell Line

2009 • 41 citations

Impaired calcium homeostasis in aged hippocampal neurons

2008 • 40 citations

Epigallocatechin gallate inhibits endothelial exocytosis

2008 • 40 citations

In Vitro Effects of Resveratrol on the Viability and Infectivity of the Microsporidian Encephalitozoon cuniculi

2004 • 37 citations

Antioxidants: A Tale of Two Stories

2007 • 37 citations

The modulation of endothelial cell gene expression by green tea polyphenol‐EGCG

2008 • 36 citations

Amyloid precursor protein cross‐linking stimulates beta amyloid production and pro‐inflammatory cytokine release in monocytic lineage cells

2006 • 36 citations

Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts

2005 • 34 citations

trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation

2008 • 29 citations

Beta-amyloid as a molecular therapeutic target in Alzheimer's disease

2009 • 27 citations

The ecological stress theory of aging and hormesis: an energetic evolutionary model

2007 • 27 citations

Age-dependent different action of curcumin in thyroid of rat.

2008 • 21 citations

Dna damage in human mononuclear cells induced by bacterial endotoxin

2008 • 17 citations

Physiological Carotid Body Denervation During Aging

2009 • 16 citations

The role of surface receptor stimulation on the cytotoxicity of resveratrol to macrophages

2008 • 15 citations