Aberrant Forkhead Box O1 Function Is Associated with Impaired Hepatic Metabolism

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

2004 • 1,294 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Molecular Physiology of the Regulation of Hepatic Gluconeogenesis and Glycolysis

1992 • 816 citations

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

1992 • 736 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

2003 • 711 citations

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

2002 • 616 citations

Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

2005 • 602 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 570 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

FoxO1 Regulates Multiple Metabolic Pathways in the Liver

2006 • 480 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

2006 • 414 citations

The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

1995 • 339 citations

SREBPs suppress IRS-2-mediated insulin signalling in the liver

2004 • 310 citations

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

1994 • 297 citations

Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

2002 • 291 citations

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

1999 • 289 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

2004 • 263 citations

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms

2004 • 224 citations

Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

2003 • 207 citations

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

2003 • 204 citations

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

2006 • 172 citations

A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction

2000 • 163 citations

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

2001 • 162 citations

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*

1999 • 146 citations

Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

2003 • 109 citations

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

2001 • 108 citations

PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1

2006 • 106 citations

Fat depot-specific expression of adiponectin is impaired in zucker fatty rats

2003 • 78 citations

Insulin Inhibition of Transcription Stimulated by the Forkhead Protein Foxo1 Is Not Solely due to Nuclear Exclusion

2003 • 63 citations

Hepatic insulin expression improves glycemic control in type 1 diabetic rats

2001 • 47 citations

Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats

2002 • 44 citations

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele

1997 • 35 citations

Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia

1998 • 34 citations