Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 570 citations

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

2002 • 555 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 517 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 483 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

2002 • 435 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX

2001 • 318 citations

Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin

2000 • 277 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

FOXO Forkhead Transcription Factors Induce G2-M Checkpoint in Response to Oxidative Stress

2002 • 265 citations

[30] Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin

1993 • 254 citations

Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B

1999 • 242 citations

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

2002 • 240 citations

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

2001 • 234 citations

Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways

2001 • 217 citations

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

2001 • 205 citations

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

2001 • 186 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*

1999 • 146 citations

ANTHEPROT: An integrated protein sequence analysis software with client/server capabilities

2001 • 134 citations

Analysis of hepatocyte nuclear factor-3β protein domains required for transcriptional activation and nuclear targeting

1995 • 127 citations

Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

2001 • 115 citations

Functional analysis of glucocorticoid and insulin response sequences in the rat insulin-like growth factor-binding protein-1 promoter.

1994 • 92 citations

Hepatocyte Nuclear Factor-3 (HNF-3) Binds to the Insulin Response Sequence in the IGF Binding Protein-1 (IGFBP-1) Promoter and Enhances Promoter Function

1994 • 91 citations

Transport pathways of macromolecules between the nucleus and the cytoplasm

1999 • 87 citations

Insulin Regulation of Gene Expression through the Forkhead Transcription Factor Foxo1 (Fkhr) Requires Kinases Distinct from Akt

2001 • 81 citations

An mRNA Splice Variant of the AFX Gene with Altered Transcriptional Activity

2002 • 23 citations