Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

1990 • 603 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

1996 • 236 citations

Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene

1995 • 235 citations

Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.

1996 • 215 citations

An Alternate Promoter in the Glucokinase Gene Is Active in the Pancreatic β Cell

1989 • 210 citations

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

1996 • 207 citations

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

1993 • 202 citations

Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity

1987 • 201 citations

Regulation of glucokinase in liver.

1976 • 197 citations

Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.

1993 • 191 citations

Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans.

1989 • 181 citations

Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.

1995 • 177 citations

Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin.

1993 • 164 citations

Correction of diabetic alterations by glucokinase.

1996 • 151 citations

Regulation of Glucokinase in Liver* *This review will be limited in scope to only the high Km glucose–ATP phosphotransferase found in liver of many animal species, and will dwell mainly on regulatory aspects. For a broader perspective on other hexokinase types, the reader is referred to the comprehensive review by Walker (165). Further material will be found in a recent review by Ureta (155a) on the phylogeny and ontogenesis of vertebrate hexokinase.

1976 • 142 citations

Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene

1995 • 135 citations

Liver Glucokinase: Decreased Activity in Patients with Type II Diabetes

1995 • 131 citations

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

1994 • 125 citations

Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs

1978 • 124 citations

13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.

1994 • 110 citations

Glucose regulates glucokinase activity in cultured islets from rat pancreas.

1990 • 101 citations

Expression of Human Hepatic Glucokinase in Transgenic Mice Liver Results in Decreased Glucose Levels and Reduced Body Weight

1997 • 99 citations

Glucokinase Mutations, Insulin Secretion, and Diabetes Mellitus

1996 • 97 citations

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

1980 • 94 citations

Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats.

1992 • 87 citations

Assessment of insulin sensitivity in glucokinase-deficient subjects

1996 • 68 citations

Glucosamine-Induced Inhibition of Liver Glucokinase Impairs the Ability of Hyperglycemia to Suppress Endogenous Glucose Production

1996 • 62 citations

Hepatic Overexpression of Insulin-like Growth Factor-II in Adulthood Increases Basal and Insulin-stimulated Glucose Disposal in Conscious Mice

1996 • 51 citations

Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

1994 • 49 citations

Isocratic high-performance liquid chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine disphosphate glucose in tissue extracts

1989 • 33 citations

Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice

1995 • 29 citations