Thermostability of a Nuclear‐Targeted Luciferase Expressed in Mammalian Cells

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

A conserved tripeptide sorts proteins to peroxisomes.

1989 • 1,113 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

1982 • 754 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

Heat‐shock proteins as molecular chaperones

1994 • 551 citations

Stress proteins in biology and medicine

1990 • 502 citations

Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell

1994 • 423 citations

hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery

1984 • 400 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

Prevention of Protein Denaturation Under Heat Stress by the Chaperonin Hsp60

1992 • 299 citations

Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins

1985 • 265 citations

Casein kinase II is a predominantly nuclear enzyme.

1992 • 208 citations

Thermotolerance in mammalian cells protein denaturation and aggregation, and stress proteins

1993 • 188 citations

Protein Denaturation during Heat Shock and Related Stress

1989 • 166 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity.

1993 • 132 citations

Thermal analysis of CHL V79 cells using differential scanning calorimetry: Implications for hyperthermic cell killing and the heat shock response

1988 • 130 citations

Renaturation of denatured λ repressor requires heat shock proteins

1990 • 123 citations

Gene Transfer and Expression

1990 • 120 citations

Cells Overexpressing Hsp27 Show Accelerated Recovery from Heat-Induced Nuclear-Protein Aggregation

1994 • 114 citations

The Search for Critical Cellular Targets Damaged by Heat

1989 • 111 citations

Heat-shock induced proteins present in the cell nucleus of Chironomus tentans salivary gland

1979 • 111 citations

Protein Denaturation During Heat Shock and Related Stress

1990 • 91 citations

The Relationship of Increased Nuclear Protein Content Induced by Hyperthermia to Killing of HeLa S3 Cells

1989 • 90 citations

Denaturation of proteins during heat shock. In vivo recovery of solubility and activity of reporter enzymes

1991 • 82 citations

ATP‐dependent protein refolding activity in reticulocyte lysate

1993 • 67 citations

Heat-induced Alterations in DNA Polymerase Activity of HeLa Cells and of Isolated Nuclei. Relation to Cell Survival

1985 • 63 citations

Characterization of a heat shock-induced insoluble complex in the nuclei of cells

1987 • 54 citations

Increased thermal aggregation of proteins in ATP‐depleted mammalian cells

1994 • 53 citations

Heat stress induces hsc70/nuclear topoisomerase Icomplex formation in vivo: evidence for hsc70-mediated, ATP-independentreactivation in vitro.

1994 • 51 citations

Importance of the ATP-Binding Domain and Nucleolar Localization Domain of HSP72 in the Protection of Nuclear Proteins against Heat-Induced Aggregation

1994 • 44 citations

Heat Shock-induced Appearance of RNA Polymerase II in Karyoskeletal Protein-enriched (Nuclear “Matrix”) Fractions Correlates with Transcriptional Shutdown in Drosophila melanogaster

1989 • 43 citations

Initial characterization of heat‐induced excess nuclear proteins in HeLa cells

1992 • 39 citations

Chaperonin from Thermus thermophilus can protect several enzymes from irreversible heat denaturation by capturing denaturation intermediate.

1993 • 25 citations

Targeting of cloned firefly luciferase to yeast mitochondria

1990 • 23 citations