Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

A formaldehyde - glutaraldehyde fixative of high osmolarity for use in electron microscopy

1965 • 5,954 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

A Drosophila model of Parkinson's disease

2000 • 2,062 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Protein misfolding, evolution and disease

1999 • 1,948 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1995 • 1,266 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright

2001 • 1,048 citations

Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation

2001 • 1,044 citations

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1998 • 996 citations

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1998 • 949 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

2000 • 767 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

The Pathogenesis of Senile Plaques

1997 • 717 citations

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

2000 • 714 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

2001 • 675 citations

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

2000 • 629 citations

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

1998 • 599 citations

α-Synuclein Membrane Interactions and Lipid Specificity

2000 • 571 citations

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

1996 • 563 citations

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

2000 • 561 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Neuropathology in mice expressing human alpha-synuclein.

2000 • 499 citations

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.

2000 • 483 citations

Laying it on thick

1999 • 471 citations

Neuropathology in Mice Expressing Human α-Synuclein

2000 • 456 citations

The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

2000 • 445 citations

Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

2000 • 427 citations

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

1999 • 421 citations

A detergent-insoluble membrance compartment contains Aβ in vivo

1998 • 394 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores

1996 • 377 citations

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

1998 • 350 citations

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

1997 • 322 citations

α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

2001 • 310 citations

Widespread Alterations of α-Synuclein in Multiple System Atrophy

1999 • 296 citations

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

2001 • 279 citations

Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins

2001 • 274 citations

In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

2000 • 264 citations

Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

1998 • 242 citations

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

1998 • 240 citations

Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons

2000 • 239 citations

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease

2000 • 219 citations

Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System

1996 • 202 citations

α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei

2001 • 150 citations

Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components.

1999 • 140 citations

Accelerated Accumulation of Amyloid β Proteins on Oxidatively Damaged Lipid Membranes

2000 • 132 citations

Mutated -synuclein gene in two Greek kindreds with familial PD: Incomplete penetrance?

1999 • 130 citations

A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.

2000 • 125 citations

α‐Synuclein Immunoisolation of Glial Inclusions from Multiple System Atrophy Brain Tissue Reveals Multiprotein Components

1999 • 115 citations

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

1992 • 98 citations

Antioxidant enzymatic systems in neuronal and glial cell-enriched fractions of rat brain during aging

1990 • 93 citations

Tip60 and HDAC7 Interact with the Endothelin Receptor A and May Be Involved in Downstream Signaling

2001 • 57 citations

Biogenesis of Synaptic-like Microvesicles in Perforated PC12 Cells

1998 • 34 citations