Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion

1972 • 1,932 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

1996 • 1,480 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1995 • 1,266 citations

A simple method for the preparation of homogeneous phospholipid vesicles

1977 • 861 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Lipids of nervous tissue: Composition and metabolism

1985 • 725 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

1998 • 647 citations

Amphipathic helix motif: Classes and properties

1990 • 634 citations

High-frequency firing helps replenish the readily releasable pool of synaptic vesicles

1998 • 613 citations

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

1998 • 599 citations

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

2000 • 561 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

1998 • 515 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

Phospholipase D: molecular and cell biology of a novel gene family

2000 • 495 citations

Synucleins in synaptic plasticity and neurodegenerative disorders

1999 • 430 citations

Regulation of Phospholipase D2: Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins

1998 • 427 citations

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

1999 • 421 citations

Calcium Dependence and Recovery Kinetics of Presynaptic Depression at the Climbing Fiber to Purkinje Cell Synapse

1998 • 417 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

Modifications of proteins by polyunsaturated fatty acid peroxidation products

2000 • 323 citations

[74] Spectrophotometric determination of avidin and biotin

1970 • 308 citations

Antibodies to ?-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

1999 • 290 citations

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

1997 • 234 citations

The nervous system has an absolute molecular species requirement for proper function

1995 • 141 citations

Sterol to Phospholipid Molar Ratios of L Cells with Qualitative and Quantitative Variations of Cellular Sterol

1974 • 132 citations

Effects of Acceptor Particle Size on the Efflux of Cellular Free Cholesterol

1995 • 128 citations

Two Actions of Calcium Regulate the Supply of Releasable Vesicles at the Ribbon Synapse of Retinal Bipolar Cells

1999 • 126 citations

Identification of a Novel Process Limiting the Rate of Synaptic Vesicle Cycling at Hippocampal Synapses

1999 • 99 citations

Synoretin—A New Protein Belonging to the Synuclein Family

1999 • 98 citations

How is protein kinase C activated in CNS

1993 • 57 citations