ROLE OF MACROPHAGES IN COMPLICATIONS OF TYPE 2 DIABETES

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

Mycophenolate mofetil and its mechanisms of action

2000 • 1,328 citations

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.

1994 • 1,125 citations

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury

2003 • 518 citations

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

2000 • 472 citations

Expression of Advanced Glycation End Products and Their Cellular Receptor RAGE in Diabetic Nephropathy and Nondiabetic Renal Disease

2000 • 468 citations

Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy

2005 • 369 citations

The Receptor RAGE as a Progression Factor Amplifying Arachidonate-Dependent Inflammatory and Proteolytic Response in Human Atherosclerotic Plaques

2003 • 367 citations

Diabetic and nondiabetic lumbosacral radiculoplexus neuropathies: New insights into pathophysiology and treatment

2002 • 345 citations

Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis

2004 • 306 citations

Macrophage accumulation in human progressive diabetic nephropathy

2006 • 291 citations

The breakdown of pre‐existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes

2003 • 268 citations

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

2005 • 267 citations

New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E–Knockout Mice

2001 • 244 citations

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice

2006 • 237 citations

Beneficial impact of spironolactone in diabetic nephropathy

2005 • 226 citations

Human Monocytes/Macrophages Release TNF-α in Response to Ox-LDL

1996 • 211 citations

Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy

2004 • 191 citations

Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis

2004 • 190 citations

Tumor Necrosis Factor-α Promotes Macrophage-Induced Vascular Smooth Muscle Cell Apoptosis by Direct and Autocrine Mechanisms

2003 • 185 citations

Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344

2005 • 176 citations

Spironolactone Prevents Diabetic Nephropathy through an Anti-Inflammatory Mechanism in Type 2 Diabetic Rats

2006 • 168 citations

Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice

2003 • 153 citations

Interactions between Angiotensin II and NF-κB–Dependent Pathways in Modulating Macrophage Infiltration in Experimental Diabetic Nephropathy

2004 • 147 citations

Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts.

1984 • 139 citations

Inflammatory vasculopathy in multifocal diabetic neuropathy

2003 • 129 citations

Effect of Eplerenone, a Selective Aldosterone Blocker, on Blood Pressure, Serum and Macrophage Oxidative Stress, and Atherosclerosis in Apolipoprotein E–Deficient Mice

2003 • 127 citations

Subacute Diabetic Proximal Neuropathy

1997 • 107 citations

Advanced Glycation End Products-Induced Gene Expression of Scavenger Receptors in Cultured Human Monocyte-Derived Macrophages

2000 • 102 citations

Immunohistochemical and Morphometric Evaluations of Coronary Atherosclerotic Plaques Associated with Myocardial Infarction and Diabetes Mellitus

1998 • 81 citations

Aqueous levels of macrophage migration inhibitory factor and monocyte chemotactic protein‐1 in patients with diabetic retinopathy

2004 • 76 citations

Statin Inhibition of Fc Receptor–Mediated Phagocytosis by Macrophages Is Modulated by Cell Activation and Cholesterol

2004 • 69 citations

Advanced glycosylation end products induced tissue factor expression in human monocyte-like U937 cells and increased tissue factor expression in monocytes from diabetic patients

1998 • 66 citations

Mycophenolate mofetil ameliorates nephropathy in the obese Zucker rat

2005 • 63 citations

Mycophenolate mofetil treatment reduces cholesterol-induced atherosclerosis in the rabbit

2000 • 61 citations

Cells of the Immune System and Their Cytokines in Epiretinal Membranes and in the Vitreous of Patients with Proliferative Diabetic Retinopathy

1993 • 55 citations

Combination Therapy with Aldosterone Blockade and Renin-Angiotensin Inhibitors Confers Organ Protection

2006 • 55 citations

Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy

2005 • 51 citations

Long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats

2003 • 51 citations

Induction of TNFα and IL-1β mRNA in monocytes by methylglyoxal- and advanced glycated endproduct-modified human serum albumin

1997 • 41 citations

The Effect of Angiotensin II Receptor Blockade on an End-Stage Renal Failure Model of Type 2 Diabetes

2006 • 41 citations

Release of superoxide radicals by mouse macrophages stimulated by oxidative modification of glycated low density lipoproteins

1995 • 29 citations

Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: A possible role in ocular neovascularization

2002 • 26 citations

Renoprotective effects of combination of angiotensin converting enzyme inhibitor with mycophenolate mofetil in diabetic rats

2006 • 22 citations

Advanced Glycation: How are we Progressing to Combat this Web of Sugar Anomalies in Diabetic Nephropathy

2004 • 10 citations