Selective Natrexone-Derived Opioid Receptor Antagonists

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

ACTH: A SHORT INTRODUCTORY REVIEW*

1977 • 389 citations

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

1984 • 361 citations

Dynorphin-(1–13) induces spontaneous feeding in rats

1981 • 225 citations

Recent developments in the design of receptor specific opioid peptides

1989 • 225 citations

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone

1978 • 148 citations

Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity

1988 • 137 citations

Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

1990 • 135 citations

Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury

1990 • 126 citations

Synthesis and pharmacologic characterization of an alkylating analog chlornaltrexamine, of naltrexone with ultralong-lasting narcotic antagonist properties

1979 • 105 citations

Role of spacer and address components in peptidomimetic .delta.-opioid receptor antagonists related to naltrindole

1991 • 97 citations

Nor-binaltorphimine decreases deprivation and opioid-induced feeding

1990 • 91 citations

Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors

1986 • 88 citations

Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent

1985 • 88 citations

Suppression of nocturnal, palatable and glucoprivic intake in rats by the κ opioid antagonist, nor-binaltorphamine

1990 • 87 citations

Evidence for two subtypes of δ opioid receptors in rat brain

1991 • 79 citations

Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action.

1989 • 75 citations

Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway

1990 • 74 citations

Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.

1984 • 71 citations

Intrathecal dynorphin A1–13 and dynorphin A3–13 reduce rat spinal cord blood flow by non-opioid mechanisms

1987 • 64 citations

Antagonism of swim-stress-induced antinociception by the δ-opioid receptor antagonist naltrindole in adult and young rats

1990 • 63 citations

Antitussive effects of two specific κ-opioid agonists, U-50,488H and U-62,066E, in rats

1990 • 52 citations

Role of the spacer in conferring .kappa. opioid receptor selectivity to bivalent ligands related to norbinaltorphimine

1991 • 51 citations

Selective kappa antagonist properties of nor-binaltorphimine in the rat mes seizure model

1989 • 51 citations

Exploring δ-receptor function using the selective opioid antagonist naltrindole

1989 • 49 citations

Stereochemical studies on medicinal agents. 31. Only one pharmacophore is required for the .kappa. opioid antagonist selectivity of norbinaltorphimine

1988 • 47 citations

Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

1990 • 47 citations

Kappa opioid receptors stimulate phosphoinositide turnover in rat brain

1990 • 42 citations

Dynorphin-selective inhibition of adenylyl cyclase in guinea pig cerebellum membranes.

1989 • 40 citations

Endogenous opiates: 1988

1989 • 37 citations

Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.

1988 • 37 citations

Modulation of Histamine Release in the Rat Brain by K‐Opioid Receptors

1990 • 32 citations

Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat

1989 • 31 citations

Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.

1989 • 30 citations

Selective opioid antagonist effects on opioid-induced inhibition of release of norepinephrine in guinea pig cortex

1989 • 28 citations

A novel pyrrole synthesis via reaction of ketones with N-aminoimides

1986 • 22 citations

Naloxone produces protracted tolerance in mice treated with a single dose of morphine.

1990 • 11 citations