Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family

1989 • 955 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Alternative splicing directs the expression of two D2 dopamine receptor isoforms

1989 • 692 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Multiple D2 dopamine receptors produced by alternative RNA splicing

1989 • 642 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

The dopamine D2 receptor: two molecular forms generated by alternative splicing.

1989 • 596 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Cloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane Domain

1989 • 568 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

The mas oncogene encodes an angiotensin receptor

1988 • 390 citations

Structure and functional expression of cloned rat serotonin 5HT-2 receptor.

1988 • 381 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

The opsin family of proteins

1986 • 245 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

1987 • 173 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

1988 • 160 citations

Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents.

1987 • 158 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

1989 • 155 citations

Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.

1988 • 153 citations

Propylbenzilylcholine Mustard Labels an Acidic Residue in Transmembrane Helix 3 of the Muscarinic Receptor

1989 • 146 citations

Structure-Function Analysis of the -Adrenergic Receptor

1988 • 145 citations

A Single Amino Acid Substitution in the β-Adrenergic Receptor Promotes Partial Agonist Activity from Antagonists

1989 • 134 citations

Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor

1988 • 128 citations

The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.

1988 • 121 citations

Talking point Multi-spanning membrane proteins: How accurate are the models?

1988 • 107 citations

Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

1977 • 104 citations

Evidence for essential disulfide bonds in beta1-adrenergic receptors of turkey erythrocyte membranes. Inactivation by dithiothreitol.

1979 • 101 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

Inhibition of magnesium uptake by beta-adrenergic agonists and prostaglandin E1 is not mediated by cyclic AMP.

1980 • 94 citations

Differential regulation of beta 1- and beta 2-adrenergic receptor protein and mRNA levels by glucocorticoids during 3T3-F442A adipose differentiation.

1990 • 92 citations

Redistribution of muscarinic acetylcholine receptors on human fibroblasts induced by regulatory ligands

1987 • 81 citations

Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

1990 • 76 citations

Human beta 2-adrenergic receptors expressed in Escherichia coli membranes retain their pharmacological properties.

1988 • 69 citations

Purification of muscarinic acetylcholine receptors by affinity chromatography.

1983 • 68 citations

Expression of Human β1 and β2 Adrenergic Receptors in E. Coli As a New Tool for Ligand Screening

1989 • 58 citations

Functional domains of rhodopsin

1982 • 56 citations

Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet .alpha.2-adrenergic receptor

1989 • 46 citations

Affinity Chromatography of the β‐Adrenergic Receptor from Turkey Erythrocytes

1979 • 40 citations

Regulation of retinal transducin by C-terminal peptides of rhodopsin

1985 • 35 citations

Molecular Biology of Adrenergic Receptors

1988 • 29 citations

Functional Role of Muscarinic Acetylcholine Receptor Subtype Diversity

1988 • 28 citations

CGEMA and VGAP: a Colour Graphics Editor for Multiple Alignment using a Variable GAP penalty. Application to the muscarinic acetylcholine receptor

1990 • 20 citations

Regulation of beta-adrenergic receptors during exposure of astrocytoma cells to catecholamines.

1984 • 7 citations

Adrenergic receptors: Some similarities and surprises

1986 • 7 citations