Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer.

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Validation of Tissue Microarray Technology in Breast Carcinoma

2000 • 800 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

2002 • 592 citations

Tissue Microarrays for Rapid Linking of Molecular Changes to Clinical Endpoints

2001 • 555 citations

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1998 • 513 citations

Brief, high‐temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues

1994 • 479 citations

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

2000 • 432 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

1993 • 379 citations

A novel germ line juxtamembrane Met mutation in human gastric cancer

2000 • 330 citations

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

2000 • 330 citations

Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor

1997 • 271 citations

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

2002 • 269 citations

Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.

1999 • 250 citations

Purification and Characterization of a Complex Containing Matriptase and a Kunitz-type Serine Protease Inhibitor from Human Milk

1999 • 243 citations

Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.

1993 • 191 citations

Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo

2001 • 188 citations

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.

2002 • 186 citations

Prometastatic Effect ofN-Acetylglucosaminyltransferase V Is Due to Modification and Stabilization of Active Matriptase by Adding β1–6 GlcNAc Branching

2002 • 172 citations

Expression of scatter factor and c-met receptor in benign and malignant breast tissue.

1997 • 164 citations

Characterization of a Novel, Membrane-bound, 80-kDa Matrix-degrading Protease from Human Breast Cancer Cells

1997 • 132 citations

Amplification of Tissue by Construction of Tissue Microarrays

2001 • 130 citations

Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma.

2000 • 128 citations

Expression of the hepatocyte growth factor/c‐Met pathway is increased at the cancer front in breast carcinoma

2001 • 124 citations

Ovarian Tumor Cells Express a Transmembrane Serine Protease: A Potential Candidate for Early Diagnosis and Therapeutic Intervention

2001 • 82 citations

Overexpression of the Hepatocyte Growth Factor (HGF) Receptor (Met) and Presence of a Truncated and Activated Intracellular HGF Receptor Fragment in Locally Aggressive/Malignant Human Musculoskeletal Tumors

2000 • 80 citations

Hepatocyte growth factor/scatter factor expression in human mammary epithelium.

1994 • 70 citations

Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).

1994 • 65 citations

Scatter factor protein levels in human breast cancers: clinicopathological and biological correlations.

1996 • 56 citations

Hepatocyte growth factor is predominantly expressed by the carcinoma cells in non–small-cell lung cancer

2001 • 49 citations

Constitutive Activation of c-Met in Liver Metastatic B16 Melanoma Cells Depends on Both Substrate Adhesion and Cell Density and Is Regulated by a Cytosolic Tyrosine Phosphatase Activity

1996 • 34 citations

Missense Mutation of the MET Gene Detected in Human Glioma

2000 • 23 citations