Overexpression of the Hepatocyte Growth Factor (HGF) Receptor (Met) and Presence of a Truncated and Activated Intracellular HGF Receptor Fragment in Locally Aggressive/Malignant Human Musculoskeletal Tumors

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Soft tissue tumors

1995 • 813 citations

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

1998 • 583 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Frequent amplification of the c-met gene in scirrhous type stomach cancer

1992 • 335 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Induction of Hepatocyte Growth Factor in Fibroblasts by Tumor-derived Factors Affects Invasive Growth of Tumor Cells : In Vitro Analysis of Tumor-Stromal Interactions

1998 • 291 citations

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1998 • 285 citations

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.

1995 • 281 citations

Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

1997 • 221 citations

Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung

1998 • 187 citations

The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation.

1991 • 187 citations

C-terminal truncated forms of Met, the hepatocyte growth factor receptor.

1991 • 165 citations

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

1993 • 159 citations

Gene amplification in gastric and esophageal adenocarcinomas.

1990 • 155 citations

Expression of the C-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression

1997 • 153 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing.

1991 • 139 citations

Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas

1994 • 128 citations

Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas.

1996 • 124 citations

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

1996 • 112 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.

1996 • 87 citations

Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors.

1997 • 77 citations

The HGF receptor family: unconventional signal transducers for invasive cell growth

1996 • 72 citations

Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site.

1994 • 67 citations

Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).

1994 • 65 citations

Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors

1997 • 64 citations

Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

1986 • 61 citations

Coexpression of HGF and c‐Met/HGF receptor in human bone and soft tissue tumors

1998 • 61 citations

Insulin-Like Growth Factors Stimulate Expression of Hepatocyte Growth Factor But Not Transforming Growth Factor β1 in Cultured Hepatic Stellate Cells*

1997 • 58 citations

C-Terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor

1991 • 52 citations

The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis

1995 • 49 citations

The Tyrosine Kinase Encoded by the MET Proto-Oncogene Is Activated by Autophosphorylation

1991 • 45 citations

Amplification of the met gene in glioma

1995 • 44 citations

Trisomy 7-Harbouring Non-Random Duplication of the Mutant MET Allele in Hereditary Papillary Renal Carcinomas

1999 • 42 citations

Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum.

1994 • 40 citations

Epithelial-Mesenchymal Interactions in Cancer

1995 • 40 citations

Alternative Splicing Generates Isoforms of the met Receptor Tyrosine Kinase Which Undergo Differential Processing

1991 • 32 citations

Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma

1998 • 29 citations

Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomas

1999 • 24 citations

Coexpression of hepatocyte growth factor and c‐Met proto‐oncogene product in synovial sarcoma

1998 • 22 citations

Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA

1997 • 17 citations