Activation of c-Jun N-terminal Kinase by 4-1BB (CD137), a T Cell Co-stimulatory Molecule

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

1998 • 218 citations

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

1995 • 178 citations

Human 4-1BB (CD137) Signals Are Mediated by TRAF2 and Activate Nuclear Factor-κB

1998 • 165 citations

ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages

1995 • 142 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

1998 • 127 citations

Receptor activator of NF‐κB recruits multiple TRAF family adaptors and activates c‐Jun N‐terminal kinase

1999 • 126 citations

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

1996 • 123 citations

Regulation of 4‐1BB expression by cell‐cell interactions and the cytokines, interleukin‐2 and interleukin‐4

1995 • 62 citations

Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding.

1992 • 61 citations

Characterization of human homologue of 4-1BB and its ligand

1995 • 48 citations

TCR Internalization Induced by Peptide/MHC Ligands Requires the Transmembrane Domains of αβ Chains of TCR, but Not the Expression of CD8 and Thy-1 Molecules

1999 • 3 citations