CTLA‐4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case–control study and segregation analysis. Evidence of a maternal effect

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

1996 • 468 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population.

1995 • 426 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus¹

1997 • 408 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves' Disease and to Type 1 Diabetes Mellitus

1997 • 270 citations

A CTLA‐4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism

1997 • 261 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

1997 • 242 citations

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

1998 • 220 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population

1995 • 203 citations

CTLA4 promoter and exon 1 dimorphisms in multiple sclerosiso

1999 • 164 citations

Association of CTLA-4 Gene A-G Polymorphism (IDDM12 Locus) With Acute-Onset and Insulin-Depleted IDDM as Well as Autoimmune Thyroid Disease (Graves' Disease and Hashimoto's Thyroiditis) in the Japanese Population

1998 • 147 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto's Thyroiditis and Addison's Disease

1997 • 130 citations

CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family‐based association study

1999 • 129 citations

CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis

1998 • 125 citations

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

2000 • 113 citations

Preferential Transmission of Diabetic Alleles within the HLA Gene Complex

1986 • 107 citations

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

1997 • 105 citations

Association Analysis of the Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) and Autoimmune Regulator-1 (AIRE-1) Genes in Sporadic Autoimmune Addison’s Disease¹

2000 • 103 citations

Genetic association of Ctla-4 to myasthenia gravis with thymoma

1998 • 86 citations

Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor

2000 • 77 citations

The Search for IDDM Susceptibility Genes: The Next Generation

1996 • 71 citations

Association Analysis of the Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) and Autoimmune Regulator-1 (AIRE-1) Genes in Sporadic Autoimmune Addison's Disease

2000 • 68 citations

No Major Role for the CTLA-4 Gene in the Association of Autoimmune Thyroid Disease With IDDM

1998 • 58 citations

CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland.

1998 • 34 citations

CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families.

1998 • 30 citations

HLA‐DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case‐control study

2000 • 24 citations

Testing parental imprinting in insulin-dependent diabetes mellitus by the marker-association-segregation-chi 2 method.

1995 • 24 citations

An improved strategy for HLA-DRB1 subtyping by digestion of PCR-amplified DNA with allele-specific restriction endonucleases.

1995 • 11 citations

[Increased risk of insulin-dependent diabetes for siblings of diabetic children with the DR 3 haplotype of the mother].

1989 • 2 citations