CTLA4 gene polymorphism correlates with the mode of onset and presence of ICA512 Ab in Japanese Type 1 diabetes

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population.

1995 • 426 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus¹

1997 • 408 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves' Disease and to Type 1 Diabetes Mellitus

1997 • 270 citations

Genetic analysis of type 1 diabetes using whole genome approaches.

1995 • 256 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

1997 • 242 citations

Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies

1996 • 219 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population

1995 • 203 citations

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.

1997 • 187 citations

Panning for gold: genome-wide scanning for linkage in type 1 diabetes

1996 • 174 citations

Association of CTLA-4 Gene A-G Polymorphism (IDDM12 Locus) With Acute-Onset and Insulin-Depleted IDDM as Well as Autoimmune Thyroid Disease (Graves' Disease and Hashimoto's Thyroiditis) in the Japanese Population

1998 • 147 citations

CTLA4 Gene Polymorphism Confers Susceptibility to Graves' Disease in Japanese

1997 • 139 citations

Autoantibodies to Glutamic Acid Decarboxylase in Patients with IDDM and Autoimmune Thyroid Disease

1994 • 132 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto's Thyroiditis and Addison's Disease

1997 • 130 citations

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

1987 • 121 citations

CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

1997 • 120 citations

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

1997 • 105 citations

CTLA‐4, a Negative Regulator of T‐Lymphocyte Activation

1996 • 91 citations

Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM

1996 • 87 citations

Genetics of Insulin-Dependent Diabetes Mellitus.

1996 • 76 citations

No Major Role for the CTLA-4 Gene in the Association of Autoimmune Thyroid Disease With IDDM

1998 • 58 citations

Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease

1994 • 47 citations

Regulation of T and B Cell Responses by Modulating Interactions between CD28/CTLA4 and Their Ligands, CD80 and CD86^a

1997 • 45 citations

Time course of islet cell antibodies and beta-cell function in non-insulin-dependent stage of type I diabetes

1987 • 29 citations