CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection

Real time quantitative PCR.

1996 • 6,155 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

1997 • 526 citations

Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.

1993 • 359 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

1987 • 287 citations

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates

1991 • 281 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor

1990 • 253 citations

Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I‐ and II‐deficient knock‐out mice: contribution of CD4 and CD8 T cells to acquired resistance

1995 • 220 citations

Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection.

1988 • 207 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

1997 • 113 citations

Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor.

1993 • 106 citations

Involvement of Cytokines in Determining Resistance and Acquired Immunity in Murine Tuberculosis

1991 • 78 citations

Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis

1995 • 67 citations

Deleted Work

1955 • 0 citations