ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity

1988 • 322 citations

Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

1991 • 293 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

1997 • 169 citations

Antigen presentation to cytotoxic T lymphocytes in vivo.

1995 • 168 citations

Roles of multiple accessory molecules in T-cell activation

1991 • 167 citations

Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

1989 • 118 citations

TransfectedDrosophilacells as a probe for defining the minimal requirements for stimulating unprimed CD8⁺T cells

1996 • 117 citations

Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation

1998 • 115 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells.

1994 • 100 citations

Remote T cell co‐stimulation via LFA‐1/ICAM‐1 and CD2/LFA‐3: Demonstration with immobilized ligand/mAb and implication in monocyte‐mediated co‐stimulation

1991 • 94 citations

SKIN ALLOGRAFT REJECTION IN CD28-DEFICIENT MICE1

1996 • 93 citations

B7‐1‐dependent co‐stimulation results in qualitatively and quantitatively different responses by CD4⁺ and CD8⁺ T cells

1997 • 77 citations

Artificial cell surface constructs for studying receptor–ligand contributions to lymphocyte activation

1997 • 54 citations

Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.

1997 • 51 citations

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.

1996 • 31 citations