Strategies for cancer therapy using carcinoembryonic antigen vaccines

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

1989 • 973 citations

Vaccinia virus: a selectable eukaryotic cloning and expression vector.

1982 • 663 citations

General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes

1984 • 652 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

1992 • 645 citations

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 • 611 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.

1996 • 521 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Durability of Complete Responses in Patients With Metastatic Cancer Treated With High-Dose Interleukin-2

1998 • 480 citations

BCG immunotherapy of bladder cancer: 20 years on

1999 • 469 citations

Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium

1997 • 409 citations

Immunotherapy of Cancer: Regression of Intradermal Tumors and Prevention of Growth of Lymph Node Metastases After Intralesional Injection of Living <italic>Mycobacterium bovis</italic>

1972 • 355 citations

Applications of pox virus vectors to vaccination: an update.

1996 • 348 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen.

1999 • 299 citations

A Phase I Trial of a Synthetic Mucin Peptide Vaccine

1996 • 268 citations

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53

1993 • 267 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence

1987 • 259 citations

Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes

1999 • 242 citations

A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

1995 • 237 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11

1999 • 231 citations

Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells

1998 • 223 citations

Carcinoembryonic Antigen in Histopathology: Immunoperoxidase Staining of Conventional Tissue Sections2

1976 • 223 citations

Antitumor Activity and Immune Responses Induced by a Recombinant Carcinoembryonic Antigen-Vaccinia Virus Vaccine

1992 • 212 citations

Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

1997 • 210 citations

Diversified prime and boost protocols using recombinant vaccinia virus and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses

1997 • 209 citations

Phase I Study in Cancer Patients of a Replication-Defective Avipox Recombinant Vaccine That Expresses Human Carcinoembryonic Antigen

1999 • 201 citations

Carcinoembryonic Antigen as a Selective Enhancer of Colorectal Cancer Metastasis

1990 • 196 citations

Problems of Delivery of Monoclonal Antibodies

1995 • 186 citations

Induction of protective host immunity to carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic mice, by immunizing with a recombinant vaccinia-CEA virus.

1999 • 181 citations

Biochemical Identification of a Mutated Human Melanoma Antigen Recognized by CD4+ T Cells

1999 • 178 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

Induction of carcinoembryonic antigen (cea)-specific cytotoxic t-lymphocyte responsesIn vitro using autologous dendritic cells loaded with cea peptide or cea rna in patients with metastatic malignancies expressing cea

1999 • 176 citations

Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site.

1988 • 173 citations

Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity

1999 • 170 citations

Prospectively randomized trial of adjuvant active‐specific immunotherapy for human colorectal cancer

1985 • 164 citations

The Carcinoembryonic Antigen Gene Family: Structure, Expression and Evolution

1988 • 156 citations

Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy.

1998 • 149 citations

Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.

1995 • 141 citations

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.

1994 • 135 citations

Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure.

1987 • 130 citations

IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.

1996 • 129 citations

Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells.

1999 • 127 citations

Immune response to a carcinoembryonic antigen polynucleotide vaccine.

1994 • 121 citations

Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen.

1997 • 119 citations

Phase I/II clinical radioimmunotherapy with an iodine-131-labeled anti-carcinoembryonic antigen murine monoclonal antibody IgG.

1997 • 117 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

Results of a phase I trial of a recombinant vaccinia virus that expresses carcinoembryonic antigen in patients with advanced colorectal cancer

1996 • 105 citations

Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte

1999 • 101 citations

Clinical applications of carcinoembryonic antigen.

1988 • 95 citations

Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity.

1995 • 93 citations

Poxviruses as expression vectors

1997 • 91 citations

Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7

1998 • 90 citations

Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4⁺; human T cell clone by the autologous MHC class II⁺ melanoma

1993 • 90 citations

Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate.

1992 • 89 citations

A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA)

1991 • 87 citations

Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model.

1987 • 86 citations

Improved immunotherapy of a recombinant carcinoembryonic antigen vaccinia vaccine when given in combination with interleukin-2.

1996 • 70 citations

Blocking CD40 – CD154 and CD80/CD86 – CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production

1999 • 67 citations

TWO CEA AND THREE NCA SPECIES, ALTHOUGH DISTINGUISHABLE BY MONOCLONAL ANTIBODIES, HAVE NEARLY IDENTICAL PEPTIDE PATTERNS

1985 • 63 citations

Dendritic Cells Pulsed with CEA Peptide Induce CEA-Specific CTL with Restricted TCR Repertoire

1998 • 61 citations

Growth inhibition of a MC-induced mouse sarcoma by TCGF (IL 2)-containing preparations

1983 • 59 citations

Bacillus Calmette—Guérin immunization in infants born to HIV-1-seropositive mothers

1991 • 59 citations

Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen.

1997 • 56 citations

Humoral and Cellular Immunity to an Encoded Protein Induced by Direct DNA Injection

1994 • 50 citations

Characterization of monoclonal antibodies to carcinoembryonic antigen with increased tumor specificity.

1986 • 49 citations

Phase I Study of Recombinant CEA Vaccinia Virus Vaccine with Post Vaccination CEA Peptide Challenge. Medical University of South Carolina, Charleston, South Carolina

1996 • 48 citations

Anti-idiotype cancer vaccines: past and future

1996 • 38 citations

Immunological properties of gene vaccines delivered by different routes

1999 • 36 citations

Immunotherapy of cancer. Generation of CEA specific CTL using CEA peptide pulsed dendritic cells.

1997 • 34 citations

Phase I Study of Monoclonal Antibody-Ricin A Chain Immunoconjugate Xomazyme-791 in Patients with Metastatic Colon Cancer

1995 • 34 citations

Studies on circulating antibody against carcinoembryonic antigen (CEA) and CEA-like antigen in cancer patients

1985 • 33 citations

Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus

1991 • 31 citations

Novel doxorubicin-monoclonal anti-carcinoembryonic antigen antibody immunoconjugate activity in vitro

1995 • 29 citations

Enhanced Immune Responses and Anti-Tumor Activity by Baculovirus Recombinant Carcinoembryonic Antigen (CEA) in Mice Primed with the Recombinant Vaccinia CEA

1994 • 28 citations

Natural antibodies against the carcinoembryonic antigen (CEA) and a related antigen, NCA, in human sera.

1987 • 20 citations

SYSTEMIC AND LOCAL IMMUNOMODULATORY EFFECTS OF INTRAVESICAL BCG THERAPY IN PATIENTS WITH SUPERFICIAL URINARY BLADDER CARCINOMAS

2000 • 20 citations

RECOMBINANT CARCINOEMBRYONIC ANTIGEN AND GRANULOCY-TE-MACROPHAGE COLONY-STIMULATING FACTOR FOR ACTIVE IMMUNIZATION OF COLORECTAL CARCINOMA PATIENTS

1995 • 16 citations

Route of Immunization and the Therapeutic Impact of Recombinant Anticancer Vaccines

1997 • 16 citations

HUMAN IMMUNE RESPONSE TO CARCINOEMBRYONIC ANTIGEN TUMOR VACCINES

1995 • 15 citations

Circulating immune complexes in patients with colorectal cancer

1983 • 14 citations

Delayed Cutaneous Hypersensitivity Reaction to Carcinoembryonic Antigen in Cancer Patients

1982 • 12 citations

Lymphokine‐activated killer cell cytotoxicity against human colon carcinomas enhanced by monoclonal antibody D612

1990 • 9 citations

Application of Genetically-Engineered Anti-CEA Antibodies for Potential Immunotherapy of Colorectal Cancer

1992 • 9 citations

The next generation of vaccines for the treatment of cancer.

1999 • 8 citations

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