Application of Genetically-Engineered Anti-CEA Antibodies for Potential Immunotherapy of Colorectal Cancer

Reshaping human antibodies for therapy

1988 • 1,555 citations

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

1991 • 1,178 citations

REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

1988 • 703 citations

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

1987 • 615 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

Identification of an Antigen from Normal Human Tissue That Crossreacts with the Carcinoembryonic Antigen

1972 • 376 citations

Cea-related antigens: Molecular biology and clinical significance

1985 • 268 citations

Humanization of a mouse monoclonal antibody by CDR–grafting: the importance of framework residues on loop conformation

1991 • 193 citations

Detection of colorectal carcinoma by emission-computerized tomography after injection of 123I-labeled Fab or F(ab')2 fragments from monoclonal anti-carcinoembryonic antigen antibodies.

1986 • 191 citations

Transfectomas Provide Novel Chimeric Antibodies

1985 • 184 citations

Enhancement of antibody-dependent cytotoxicity with a chimeric anti-GD2 antibody.

1990 • 179 citations

The immunogenicity of chimeric antibodies.

1989 • 176 citations

Monoclonal antibodies identify a cea crossreacting antigen of 95 kD (NCA‐95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 kD

1984 • 151 citations

Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries.

1991 • 144 citations

Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering

1987 • 136 citations

Humanized antibodies for antiviral therapy.

1991 • 126 citations

Clinical value of immunoscintigraphy in colorectal carcinoma patients: a prospective study.

1989 • 103 citations

Phase I trial of murine monoclonal antibody L6 in breast, colon, ovarian, and lung cancer.

1990 • 102 citations

Secretion and in vivo folding of the F_ab fragment of the antibody McPC603 in Escherichia coli: influence of disulphides and cis-prolines

1991 • 91 citations

Serum half-life and tumor localization of a chimeric antibody deleted of the CH2 domain and directed against the disialoganglioside GD2.

1990 • 83 citations

Radioimmunotherapy of human colon carcinoma by ¹³¹I‐labelled monoclonal anti‐cea antibodies in a nude mouse model

1988 • 72 citations

Imaging and therapy with monoclonal antibodies in non-hematopoietic tumors

1991 • 51 citations

DEVELOPMENT OF ANTI-IDIOTYPIC ANTIBODIES AGAINST TUMOUR ANTIGENS AND AUTOANTIGENS IN OVARIAN CANCER PATIENTS TREATED INTRAPERITONEALLY WITH MOUSE MONOCLONAL ANTIBODIES

1988 • 48 citations

Generation of a recombinant mouse‐human chimaeric monoclonal antibody directed against human carcinoembryonic antigen

1989 • 41 citations

Radioimmuno positron emission tomography with monoclonal antibodies

1991 • 40 citations

Different behaviour of mouse‐human chimeric antibody F(ab')₂ fragments of IgG₁, IgG₂ and IgG₄ sub‐class in vivo

1992 • 26 citations

Bone marrow dosimetry in rats using direct tissue counting after injection of radio-iodinated intact monoclonal antibodies or F(ab')2 fragments.

1991 • 21 citations

Monoclonal antibodies in cancer therapy

1990 • 16 citations

Chimeric univalent antibodies for treating lymphoid malignancies

1984 • 11 citations