A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA)

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

DNA cloning : a practical approach

1985 • 2,302 citations

Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

1989 • 973 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Vaccinia virus: a selectable eukaryotic cloning and expression vector.

1982 • 663 citations

General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes

1984 • 652 citations

Cellular Immunity Against Tumor Antigens

1969 • 474 citations

Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy

1981 • 377 citations

Infectious poxvirus vectors have capacity for at least 25 000 base pairs of foreign DNA

1983 • 311 citations

Live recombinant vaccinia virus protects chimpanzees against hepatitis B

1984 • 290 citations

Vaccinia Virus Expression Vectors

1987 • 272 citations

Cea-related antigens: Molecular biology and clinical significance

1985 • 268 citations

Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence

1987 • 259 citations

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: Homophilic and heterophilic adhesion

1989 • 236 citations

Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells

1984 • 234 citations

Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection

1987 • 198 citations

Active-specific immunotherapy for melanoma.

1990 • 186 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

The Carcinoembryonic Antigen Gene Family: Structure, Expression and Evolution

1988 • 156 citations

Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line.

1991 • 149 citations

Processing of the native nerve growth factor precursor to form biologically active nerve growth factor.

1988 • 139 citations

Protection of rhesus monkeys from fatal Lassa fever by vaccination with a recombinant vaccinia virus containing the Lassa virus glycoprotein gene.

1989 • 122 citations

Immunohistochemistry of Carcino-Embryonic Antigen in the Embryo, Fetus and Adult

1988 • 120 citations

Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

1988 • 110 citations

Tumour prevention and rejection with recombinant vaccinia

1987 • 101 citations

Recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy.

1988 • 98 citations

Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector.

1987 • 98 citations

Surface expression of viral glycoproteins is polarized in epithelial cells infected with recombinant vaccinia viral vectors.

1986 • 95 citations

Clinical applications of carcinoembryonic antigen.

1988 • 95 citations

Active γ-carboxylated human factor IX expressed using recombinant DNA techniques

1985 • 91 citations

Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus

1989 • 91 citations

Vaccinia viruses as vectors for vaccine antigens

1986 • 88 citations

Immunoconjugates : antibody conjugates in radioimaging and therapy of cancer

1987 • 81 citations

Expression and Cell Type—Specific Processing of Human Preproenkephalin with a Vaccinia Recombinant

1986 • 81 citations

A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes

1988 • 67 citations

Serologic mapping and biochemical characterization of the carcinoembryonic antigen epitopes using fourteen distinct monoclonal antibodies

1989 • 52 citations

Risks and benefits of vaccinia vaccine use in the worldwide smallpox eradication campaign

1989 • 50 citations

Structure of vaccinia DNA: Analysis of the viral genorne by restriction endonucleases

1978 • 46 citations

Immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (PIV3) protects patas monkeys against PIV3 infection

1988 • 44 citations

Active specific immunotherapy in malignant melanoma

1989 • 41 citations

Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97

1988 • 40 citations

Correlation of DNA hypomethylation with expression of carcinoembryonic antigen in human colon carcinoma cells.

1988 • 33 citations

Active immunotherapy in colorectal cancer

1989 • 22 citations

Expression of herpes simplex virus glycoprotein D on antigen presenting cells infected with vaccinia recombinants and protective immunity

1988 • 15 citations

Use of vaccinia virus vectors to study protein processing in human disease. Normal nerve growth factor processing and secretion in cultured fibroblasts from patients with familial dysautonomia.

1988 • 8 citations

Antigenic properties of vaccinia virus and of the virus recombinant strains expressing heterologous genes.

1988 • 6 citations