Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 • 611 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer.

1991 • 331 citations

Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles

1982 • 320 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

The discovery of MHC restriction

1997 • 281 citations

Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease

1991 • 250 citations

The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial Tumors

1998 • 235 citations

Overexpression of HER2/neu oncogene in human pancreatic carcinoma

1993 • 217 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.

1997 • 188 citations

Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

1990 • 162 citations

Expression of the c-erbB-2 (Her-2/neu) Oncoprotein in Human Prostatic Carcinoma

1993 • 159 citations

Gene amplification in gastric and esophageal adenocarcinomas.

1990 • 155 citations

Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer

1994 • 153 citations

Tumor antigens recognized by T lymphocytes

1997 • 153 citations

In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein.

1994 • 150 citations

Generation of antigen-specific CD8+ CTLs from naive precursors.

1994 • 143 citations

Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes.

1993 • 140 citations

Identification of Her-2/Neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8

1997 • 107 citations

Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.

1990 • 77 citations

Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas

1995 • 65 citations

In Vitro Immunization and Expansion of Antigen-Specific Cytotoxic T Lymphocytes for Adoptive Immunotherapy Using Peptide-Pulsed Dendritic Cells

1998 • 60 citations

Identification of GP100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primaryin vitro immunization with peptide-pulsed dendritic cells

1998 • 51 citations

In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides

1995 • 41 citations

The molecular basis of cancer immunotherapy by cytotoxic T lymphocytes

1998 • 28 citations

The Use of Epstein-Barr Virus-Transformed B Lymphocyte Cell Lines in a Peptide-Reconstitution Assay

1995 • 25 citations