Identification of Novel Cellular Targets in Biliary Tract Cancers Using Global Gene Expression Technology

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

2013 • 12,861 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Ki67 expression in breast cancer

2016 • 4,269 citations

Cancer Statistics, 2001

2001 • 3,342 citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 • 1,721 citations

Delineation of prognostic biomarkers in prostate cancer

2001 • 1,694 citations

Extensive and divergent circadian gene expression in liver and heart

2002 • 1,498 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

2000 • 1,414 citations

Diversity of gene expression in adenocarcinoma of the lung

2001 • 1,299 citations

Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application

2001 • 972 citations

Biliary Tract Cancers

1999 • 944 citations

Epidemiology and Molecular Pathology of Gallbladder Cancer

2001 • 806 citations

Cyclin D-dependent kinases, INK4 inhibitors and cancer

2002 • 770 citations

Scatter-factor and semaphorin receptors: cell signalling for invasive growth

2002 • 734 citations

Regulation of apoptosis at cell division by p34 ^cdc2 phosphorylation of survivin

2000 • 606 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

2002 • 508 citations

Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

2001 • 431 citations

Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates

1992 • 428 citations

Gemcitabine: preclinical pharmacology and mechanisms of action.

1996 • 401 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

To ERR in the estrogen pathway

2002 • 389 citations

Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

2002 • 387 citations

Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia

2002 • 361 citations

A p34cdc2 survival checkpoint in cancer

2002 • 317 citations

Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology

2002 • 296 citations

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

2000 • 296 citations

Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer.

2002 • 280 citations

HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil.

2002 • 268 citations

Germline Mutations in BMPR1A/ALK3 Cause a Subset of Cases of Juvenile Polyposis Syndrome and of Cowden and Bannayan-Riley-Ruvalcaba Syndromes*

2001 • 248 citations

Sonic hedgehog regulates gastric gland morphogenesis in man and mouse

2001 • 240 citations

Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates

1992 • 228 citations

Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development

2001 • 209 citations

Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein

1988 • 189 citations

The role of EGF-related peptides in tumor growth

2001 • 188 citations

Human ERRγ, a Third Member of the Estrogen Receptor-Related Receptor (ERR) Subfamily of Orphan Nuclear Receptors: Tissue-Specific Isoforms Are Expressed during Development and in the Adult

2000 • 187 citations

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

2002 • 183 citations

Exploring the Host Desmoplastic Response to Pancreatic Carcinoma

2002 • 182 citations

Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer.

2002 • 174 citations

[46] Isolation of differentially expressed genes

1987 • 170 citations

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

2002 • 161 citations

HOXB7: a key factor for tumor-associated angiogenic switch.

2001 • 148 citations

Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia

1996 • 140 citations

Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer.

2002 • 137 citations

Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade.

2001 • 134 citations

Establishment of a New Extrahepatic Bile Duct Carcinoma Cell Line, TFK-1.

1995 • 131 citations

Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm

2001 • 128 citations

Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin a: Comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells

2000 • 127 citations

Expression of Geminin as a Marker of Cell Proliferation in Normal Tissues and Malignancies

2002 • 119 citations

4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ

2001 • 112 citations

The LIM Domain Homeobox Gene isl-1 Is a Positive Regulator of Islet Cell-specific Proglucagon Gene Transcription

1995 • 110 citations

A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells

2001 • 107 citations

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

2002 • 105 citations

Transforming Growth Factor-β Receptor-associated Protein 1 Is a Smad4 Chaperone

2001 • 93 citations

Establishment and characterisation of six human biliary tract cancer cell lines

2002 • 83 citations

5-Alpha-reductase inhibition and prostate cancer prevention.

1994 • 74 citations

Enrichment of epithelial cells for molecular studies

1999 • 72 citations

Involvement of 85-kd cytosolic phospholipase A₂and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells

2002 • 72 citations

Biliary cancer growth factor pathways, cyclo‐oxygenase‐2 and potential therapeutic strategies

2001 • 69 citations

Control of chick tectum territory along dorsoventral axis by Sonic hedgehog

2000 • 69 citations

SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER

2001 • 65 citations

Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone

1999 • 62 citations

Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines.

2000 • 61 citations

Transforming Growth Factor-β1 Stimulates or Inhibits Cell Growth via Down- or Up-Regulation of p21/Waf1

1998 • 61 citations

Human ERR , a Third Member of the Estrogen Receptor-Related Receptor (ERR) Subfamily of Orphan Nuclear Receptors: Tissue-Specific Isoforms Are Expressed during Development and in the Adult

2000 • 58 citations

Expression of p53 and PCNA in Cholangiocarcinoma and Primary Sclerosing Cholangitis

2000 • 55 citations

Phase I clinical trial of continuous infusion cyclopentenyl cytosine

1995 • 49 citations

True

2000 • 48 citations

Isolation of differentially expressed genes in NPM‐ALK‐positive anaplastic large cell lymphoma

2002 • 48 citations

Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.

2002 • 44 citations

Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome.

2000 • 44 citations

Serum hepatocyte growth factor/scatter factor levels in small cell lung cancer patients

1997 • 43 citations

Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step

1998 • 41 citations

Going Mad withSmads

1999 • 39 citations

Expression of cytosolic and group X secretory phospholipase A2 genes in human colorectal adenocarcinomas

2002 • 35 citations

4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors and

2001 • 33 citations

Hepatocyte growth factor stimulates the invasion of gallbladder carcinoma cell lines in vitro.

1997 • 33 citations

Increased level of serum hepatocyte growth factor/scatter factor in liver cancer is associated with tumor metastasis.

1999 • 27 citations

Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen.

1998 • 22 citations

Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm

2003 • 18 citations

Cholesterol Biosynthesis from Lanosterol: Differential Inhibition of Sterol Δ8-lsomerase and Other Lanosterol-Converting Enzymes by Tamoxifen

1998 • 15 citations

Cytosolic phospholipase A2 is activated by the hepatocyte growth factor receptor-kinase in Madin Darby canine kidney cells

1997 • 12 citations

[Effect of recombinant human basic fibroblast growth factor (bFGF) on the growth of human tumor cell lines].

1996 • 6 citations

Motility factors identified in supernatants of human cholangiocarcinoma cell lines

2001 • 6 citations