Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Cancer statistics, 1997

1997 • 2,045 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Origins of Cell Polarity

1996 • 1,024 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer

2000 • 764 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

1995 • 612 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

Plakoglobin: A protein common to different kinds of intercellular adhering junctions

1986 • 508 citations

Ras effectors

1996 • 445 citations

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

1997 • 444 citations

Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

1997 • 428 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

Are desmosomes more than tethers for intermediate filaments?

2000 • 388 citations

E-Cadherin Expression in Melanoma Cells Restores Keratinocyte-Mediated Growth Control and Down-Regulates Expression of Invasion-Related Adhesion Receptors

2000 • 357 citations

Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.

1992 • 337 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Desmosomes and hemidesmosomes

1993 • 310 citations

Cell adhesion molecules in the development and progression of malignant melanoma.

1999 • 294 citations

E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro

1994 • 289 citations

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

1994 • 283 citations

Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.

1994 • 279 citations

Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus and Pemphigoid, Bullous Diseases Due to Defective Epidermal Cell Adhesion

1993 • 262 citations

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma [published erratum appears in Hum Mol Genet 1999 May;8(5):943]

1999 • 260 citations

Defining the Interactions Between Intermediate Filaments and Desmosomes

1998 • 257 citations

Cross-Talk between Adherens Junctions and Desmosomes Depends on Plakoglobin

1997 • 256 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

1997 • 237 citations

Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments

1998 • 234 citations

Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.

1996 • 227 citations

Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.

1989 • 223 citations

Human Melanoma Progression in Skin Reconstructs

2000 • 217 citations

Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth

1991 • 215 citations

Molecular map of the desmosomal plaque

1999 • 214 citations

Adenoviral Gene Transfer of β3 Integrin Subunit Induces Conversion from Radial to Vertical Growth Phase in Primary Human Melanoma

1998 • 211 citations

Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression

1993 • 206 citations

Pemphigus Vulgaris Antigen (Desmoglein 3) Is Localized in the Lower Epidermis, the Site of Blister Formation in Patients

1996 • 206 citations

Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development.

1996 • 199 citations

Desmosomal cadherins: another growing multigene family of adhesion molecules

1994 • 199 citations

The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells.

1992 • 194 citations

Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells – regulation by Rho, Rac and Rab small G proteins

1999 • 191 citations

Desmosomes: differentiation, development, dynamics and disease

1996 • 165 citations

c-erbB-2 Gene Product Directly Associates with β-Catenin and Plakoglobin

1995 • 165 citations

c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells

1994 • 162 citations

Adhesion in Development: An Historical Overview

1996 • 157 citations

Molecular events in melanoma development and progression

1998 • 152 citations

Melanoma cell lines from different stages of progression and their biological and molecular analyses

1997 • 150 citations

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

1987 • 145 citations

Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin.

1994 • 140 citations

Dynamics of intercellular communication during melanoma development

2000 • 125 citations

Met–HGF/SF: Tumorigenesis, Invasion and Metastasis

2007 • 125 citations

Progression-related expression of β3 integrin in melanomas and nevi

1999 • 121 citations

Distinct cadherin—catenin complexes in Ca²⁺ dependent cell—cell adhesion

1994 • 120 citations

E-cadherin/catenin complex in benign and malignant melanocytic lesions

1998 • 119 citations

Association of the HGF/SF Receptor, c-met, with the Cell-Surface Adhesion Molecule, E-Cadherin, and Catenins in Human Tumor Cells

1999 • 119 citations

The body language of cells: The intimate connection between cell adhesion and behavior

1995 • 112 citations

E-cadherin expression in human melanoma

1996 • 112 citations

Growth Factor–dependent Activation of αvβ3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion

1998 • 110 citations

Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase

1996 • 107 citations

Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice.

2000 • 105 citations

Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes

1998 • 103 citations

Extracellular Domain of Pemphigus Vulgaris Antigen (Desmoglein 3) Mediates Weak Homophilic Adhesion

1994 • 103 citations

Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviour

1998 • 98 citations

Hepatocyte Growth Factor/Scatter Factor‐MET Signaling in Neural Crest‐Derived Melanocyte Development

1999 • 87 citations

Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor

1992 • 83 citations

Rac1 Mediates Dendrite Formation in Response to Melanocyte Stimulating Hormone and Ultraviolet Light in a Murine Melanoma Model

1998 • 68 citations

Structured Gamma

1998 • 64 citations

Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes

2000 • 58 citations

Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).

1999 • 57 citations

Plakoglobin Binding by Human Dsg3 (Pemphigus Vulgaris Antigen) in Keratinocytes Requires the Cadherin-Like Intracytoplasmic Segment

1995 • 50 citations

Expression of desmoglein I and plakoglobin in skin carcinomas

2000 • 48 citations

Down‐regulation of desmosomal molecules in oral and pharngeal squamous cell carcinomas as a marker for tumour growth and distant metastasis

1999 • 46 citations

Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells

1998 • 45 citations

Intravenous Injection of an Adenovirus Encoding Hepatocyte Growth Factor Results in Liver Growth and Has a Protective Effect Against Apoptosis

2000 • 44 citations

Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro

1999 • 40 citations

Plasticity of Cadherin–Catenin Expression in the Melanocyte Lineage

2000 • 37 citations

Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis.

1996 • 37 citations

Immunohistochemical Staining with Monoclonal Antibody 32–2B to Desmosomal Glycoprotein 1: Its Role in the Histological Assessment of Urothelial Carcinomas

1990 • 33 citations

Loss of Invasiveness in Squamous Cell Carcinoma Cells Overexpressing Desmosomal Cadherins

1999 • 25 citations

Influence of Hepatocyte Growth Factor/Scatter Factor on the Metastatic Phenotype of B16 Melanoma Cells

1998 • 17 citations

Cadherin-dependent organization and disorganization of epithelial architecture.

1994 • 15 citations

Molecular dissection of desmosomal assembly and intermediate filament anchorage.

1998 • 10 citations

Subject Index

1993 • 2 citations