Expression of cytosolic and group X secretory phospholipase A2 genes in human colorectal adenocarcinomas

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Molecular Cell Biology

1986 • 5,808 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Molecular cell biology

1987 • 666 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Cytosolic phospholipase A2

1995 • 530 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study.

2000 • 313 citations

Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

1997 • 256 citations

Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells

2000 • 209 citations

Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer

1997 • 170 citations

Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells

1999 • 163 citations

Suppression of Intestinal Polyposis inApc Δ716 Knockout Mice by an Additional Mutation in the Cytosolic Phospholipase A2Gene

2000 • 142 citations

Deletion of cytosolic phospholipase A ₂ suppresses Apc ^Min -induced tumorigenesis

2001 • 126 citations

Cyclooxygenase, NSAIDs, and colorectal cancer

1996 • 121 citations

Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients.

1998 • 79 citations

Induction of Cytosolic Phospholipase A2 by Oncogenic Ras Is Mediated through the JNK and ERK Pathways in Rat Epithelial Cells

2001 • 68 citations

Potential role of group X secretory phospholipase A₂ in cyclooxygenase‐2‐dependent PGE₂ formation during colon tumorigenesis

2000 • 58 citations

Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli.

1996 • 53 citations

Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer.

1998 • 47 citations

Secretory Phospholipase A2 Mediates Cooperative Prostaglandin Generation by Growth Factor and Cytokine Independently of Preceding Cytosolic Phospholipase A2 Expression in Rat Gastric Epithelial Cells

2001 • 42 citations

Characterization of Group X Phospholipase A2 as the Major Enzyme Secreted by Human Keratinocytes and its Regulation by the Phorbol Ester TPA

2001 • 39 citations

Phospholipase A2 gene expression and activity in histologically normal ileal mucosa and in Crohn's ileitis.

1995 • 33 citations

Activities of phospholipase A2 and diacylglycerol lipase are increased in human colorectal cancer

1995 • 29 citations

Role of the Cytosolic Phospholipase A2-linked Cascade in Signaling by an Oncogenic, Constitutively Active Ha-Ras Isoform

2001 • 28 citations

Human homologue of a candidate for the Mom1 locus, the secretory type II phospholipase A2 (PLA2S-II), maps to 1p35-36.1/D1S199.

1995 • 25 citations

Role of K-ras mutations in colorectal carcinoma

1998 • 22 citations