RNomics: identification and function of small, non-messenger RNAs

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The Sequence of the Human Genome

2001 • 13,500 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

RNAi

2000 • 2,596 citations

Prediction of Plant MicroRNA Targets

2002 • 2,239 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

MicroRNAs in plants

2002 • 1,791 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

microRNAs

2001 • 1,653 citations

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

2002 • 1,569 citations

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

2001 • 1,430 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

2002 • 1,422 citations

Non–coding RNA genes and the modern RNA world

2001 • 1,407 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

1996 • 1,103 citations

A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli

2002 • 1,089 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

2001 • 1,055 citations

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

2001 • 1,008 citations

Gene silencing as an adaptive defence against viruses

2001 • 985 citations

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

2001 • 955 citations

Endogenous and Silencing-Associated Small RNAs in Plants[W]

2002 • 908 citations

Non‐coding RNAs: the architects of eukaryotic complexity

2001 • 815 citations

Small Nucleolar RNAs

2002 • 770 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

2001 • 745 citations

Novel small RNA-encoding genes in the intergenic regions of Escherichia coli

2001 • 743 citations

Identification of novel small RNAs using comparative genomics and microarrays

2001 • 709 citations

RNA interference—2001

2001 • 698 citations

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

2001 • 680 citations

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

2001 • 670 citations

A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis

2002 • 657 citations

The expanding snoRNA world

2002 • 652 citations

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization

2000 • 573 citations

Small RNAs Correspond to Centromere Heterochromatic Repeats

2002 • 501 citations

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End

1999 • 499 citations

Noncoding RNA gene detection using comparative sequence analysis

2001 • 482 citations

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs

2002 • 481 citations

A Computational Screen for Methylation Guide snoRNAs in Yeast

1999 • 469 citations

6S RNA Regulates E. coli RNA Polymerase Activity

2000 • 462 citations

Small RNA species of the HeLa cell: Metabolism and subcellular localization

1976 • 409 citations

Computational identification of noncoding RNAs in E. coli by comparative genomics

2001 • 396 citations

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A

2001 • 383 citations

Homologs of Small Nucleolar RNAs in Archaea

2000 • 338 citations

Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus

2002 • 334 citations

RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse

2001 • 321 citations

Regulation of RpoS by a novel small RNA: the characterization of RprA

2001 • 277 citations

Regulation of RpoS by a novel small RNA: the characterization of RprA

2001 • 262 citations

12 Antisense RNAs in bacteria and their genetic elements

2002 • 244 citations

C-terminal Extension of Truncated Recombinant Proteins in Escherichia coli with a 10Sa RNA Decapeptide

1995 • 233 citations

Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region

2002 • 224 citations

A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome

2002 • 223 citations

A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA

2001 • 215 citations

Small RNAs in Escherichia coli

1999 • 213 citations

A computational approach to identify genes for functional RNAs in genomic sequences

2001 • 196 citations

In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex

2002 • 188 citations

Noncoding RNA genes identified in AT-rich hyperthermophiles

2002 • 175 citations

Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs: lessons from the Pyrococcus genomes 1 1Edited by M. Yaniv

2000 • 161 citations

Box C/D RNA guides for the ribose methylation of archaeal tRNAs. The tRNATrp intron guides the formation of two ribose-methylated nucleosides in the mature tRNATrp

2001 • 147 citations

Experimental RNomics

2002 • 139 citations

The contribution of RNAs and retroposition to evolutionary novelties.

2003 • 138 citations

RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing

2002 • 134 citations

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains

2002 • 120 citations

Purified Box C/D snoRNPs Are Able To Reproduce Site-Specific 2′-O-Methylation of Target RNA In Vitro

2002 • 91 citations

Multiple snoRNA gene clusters from Arabidopsis.

2001 • 80 citations

A Novel Brain-specific Box C/D Small Nucleolar RNA Processed from Tandemly Repeated Introns of a Noncoding RNA Gene in Rats

2001 • 78 citations

Neuronal BC1 RNA structure: Evolutionary conversion of a tRNAAla domain into an extended stem-loop structure

2001 • 77 citations

Imprinted expression of small nucleolar RNAs in brain: Time for RNomics

2000 • 74 citations

Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2′-O-methylation sites

2001 • 70 citations

The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA

2002 • 68 citations

Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana

2001 • 66 citations

Birth of a gene: locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage

2001 • 54 citations

A novel gene organization: intronic snoRNA gene clusters from Oryza sativa

2002 • 43 citations

Comparing Vertebrate Whole-Genome Shotgun Reads to the Human Genome

2001 • 18 citations

The contribution of RNAs and retroposition to evolutionary novelties

2003 • 17 citations