Maturation and Migration of Cutaneous Dendritic Cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.

1994 • 626 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

1993 • 540 citations

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.

1987 • 523 citations

Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes

1976 • 510 citations

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1

1994 • 505 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.

1993 • 428 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.

1993 • 395 citations

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets

1994 • 391 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

1991 • 379 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

1994 • 354 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Characterization of nonlymphoid cells derived from rat peripheral lymph

1983 • 343 citations

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

1992 • 327 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization.

1993 • 279 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages

1992 • 257 citations

Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation.

1990 • 227 citations

Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

1987 • 215 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.

1990 • 193 citations

Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor.

1990 • 182 citations

Isolation and characterization of dendritic cells from mouse heart and kidney.

1994 • 179 citations

Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes.

1988 • 179 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Functional anatomy of lymph nodes. II. Peripheral lymph‐borne mononuclear cells

1978 • 164 citations

A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the langerhans cell

1979 • 161 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Lymph‐Borne Dendritic Leucocytes do Not Recirculate, but Enter the Lymph Node Paracortex to Become Interdigitating Cells

1988 • 145 citations

MIGRATION PATTERNS OF DENDRITIC LEUKOCYTES

1990 • 139 citations

Role of veiled cells in lymphocyte activation

1982 • 131 citations

The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.

1981 • 123 citations

Unusual expression of CD2 in sheep: implications for T cell interactions

1988 • 113 citations

Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen

1990 • 108 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Both Dendritic Cells and Memory T Lymphocytes Emigrate From Organ Cultures of Human Skin and Form Distinctive Dendritic-T-Cell Conjugates

1995 • 95 citations

Mechanisms of tumor necrosis factor-granulocyte-macrophage colony- stimulating factor-induced dendritic cell development

1993 • 92 citations

Potentiation of early hematopoiesis by tumor necrosis factor-alpha is followed by inhibition of granulopoietic differentiation and proliferation

1991 • 90 citations

Distribution and turnover of Langerhans cells during delayed immune responses in human skin.

1987 • 89 citations

Phenotypic characteristics of antigen-bearing cells in the draining lymph nodes of contact sensitized mice.

1990 • 85 citations

Understanding the dendritic cell lineage through a study of cytokine receptors.

1994 • 81 citations

Biology of Langerhans cells: Selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice

1983 • 71 citations

A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes.

1989 • 68 citations

Functional characteristics of the veiled cells in afferent lymph from the rat intestine.

1986 • 65 citations

Development of a Langerhans cell phenotype from peripheral blood monocytes

1992 • 63 citations

Properties of lymph-borne (veiled) dendritic cells in culture. I. Modulation of phenotype, survival and function: partial dependence on GM-CSF.

1989 • 63 citations

In vivo modulation of CD1 and MHC class II expression by sheep afferent lymph dendritic cells. Comparison of primary and secondary immune responses.

1989 • 55 citations

Large increase of Langerhans cells in human skin lymph derived from irritant contact dermatitis

1993 • 53 citations

Function of adhesion molecules lymphocyte function-associated antigen-3 and intercellular adhesion molecule-1 on human epidermal Langerhans cells in antigen-specific T cell activation.

1994 • 52 citations

Occurrence of Donor Langerhans cells in Mouse and Rat Chimeras and Their Replacement in Skin Grafts

1986 • 48 citations

Isolation and characterization of migratory human skin dendritic cells

1994 • 47 citations

T Cell Priming In Situ by Intratracheally Instilled Antigen-pulsed Dendritic Cells

1993 • 44 citations

T Lymphocyte-Derived Colony-Stimulating Factors

1990 • 39 citations

Spontaneous cluster formation of dendritic (veiled) cells and lymphocytes from skin lymph obtained from dogs with chronic lymphedema.

1992 • 6 citations