The BB1 Monoclonal Antibody Recognizes Both Cell Surface CD74 (MHC Class II-Associated Invariant Chain) as Well as B7-1 (CD80), Resolving the Question Regarding a Third CD28/CTLA-4 Counterreceptor

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Leukocyte Typing II

1986 • 688 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

1989 • 487 citations

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1991 • 335 citations

B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas.

1982 • 297 citations

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

1992 • 285 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes

1994 • 246 citations

The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44

1993 • 245 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

B7, a B-cell-restricted antigen that identifies preactivated B cells.

1987 • 211 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease.

1984 • 175 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 173 citations

Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.

1994 • 168 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

1996 • 161 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 149 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Both Extracellular Immunoglobin-like Domains of CD80 Contain Residues Critical for Binding T Cell Surface Receptors CTLA-4 and CD28

1995 • 143 citations

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

1990 • 138 citations

The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.

1984 • 124 citations

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo.

1993 • 103 citations

In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease

1994 • 102 citations

Polypeptides on human B lymphocytes associated with cell activation

1986 • 98 citations

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen

1994 • 83 citations

Differential modulation of keratinocyte intercellular adhesion molecule-i expression by gamma interferon and phorbol ester: evidence for involvement of protein kinase C signal transduction

1990 • 80 citations

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

1991 • 72 citations

In situ expression of B7/BB1 on antigenpresenting cells and activated B cells: an immunohistochemical study

1993 • 71 citations

Transport properties of free and MHC class ll-associated oligomers containing different isoforms of human invariant chain

1994 • 69 citations

Surface expression of the invariant chain (CD74) is independent of concomitant expression of major histocompatibility complex class II antigens.

1995 • 66 citations

Human B Cell and B Cell Blast-Associated Surface Molecules Defined with Monoclonal Antibodies

1984 • 58 citations

Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).

1991 • 53 citations

Definition and identification of homology domains

1988 • 46 citations

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.

1995 • 45 citations

Phorbol-12-Myristate-13-Acetate-Treated Human Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation

1993 • 42 citations

mAb 104, a new monoclonal antibody, recognizes the B7 antigen that is expressed on activated B cells and HTLV-1-transformed T cells.

1990 • 41 citations

Chromosome mapping of cell membrane antigens expressed on activated B cells

1985 • 39 citations

Sequences homologous to class II MHC W, X, and Y elements mediate constitutive and IFN-gamma-induced expression of human class II-associated invariant chain gene.

1991 • 38 citations

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21

1992 • 34 citations

The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

1997 • 33 citations

Cell surface expression of invariant gamma-chain of class II histocompatibility antigens in human skin.

1986 • 30 citations

Molecular Cloning and Comparative Analysis of the Rhesus Macaque Costimulatory Molecules CD80 (B7-1) and CD86 (B7-2)

1997 • 6 citations

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21

1992 • 2 citations