Selective degradation of mitochondria by mitophagy

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Mechanisms of Neuroprotective Action of Vitamin D₃

2004 • 5,057 citations

Development by Self-Digestion

2004 • 3,562 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

The mitochondrial permeability transition

1995 • 2,412 citations

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

2003 • 2,218 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Autophagy in cell death: an innocent convict?

2005 • 1,655 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Inhibition of Macroautophagy Triggers Apoptosis

2005 • 1,581 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Autophagy as a cell death and tumor suppressor mechanism

2004 • 1,375 citations

LC3 conjugation system in mammalian autophagy

2004 • 1,331 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Oxidative Phosphorylation at the fin de siècle

1999 • 1,256 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

2005 • 1,180 citations

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2004 • 1,045 citations

Mitochondrial ROS-induced ROS release: An update and review

2006 • 1,009 citations

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

2001 • 979 citations

Role for Rab7 in maturation of late autophagic vacuoles

2004 • 844 citations

Escape of Intracellular Shigella from Autophagy

2004 • 798 citations

Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D

2005 • 787 citations

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

2006 • 776 citations

Another way to die: autophagic programmed cell death

2005 • 744 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?

2006 • 677 citations

Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

The mitochondrial permeability transition initiates autophagy in rat hepatocytes

2001 • 596 citations

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1995 • 496 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Does Autophagy Contribute To Cell Death?

2005 • 439 citations

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

2002 • 433 citations

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

2004 • 406 citations

Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

2002 • 368 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

1971 • 335 citations

Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration.

1968 • 328 citations

Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes

2006 • 322 citations

Two ubiquitin-like conjugation systems essential for autophagy

2004 • 304 citations

Photodynamic Therapy-induced Apoptosis in Epidermoid Carcinoma Cells

2001 • 291 citations

A proposed refinement of the mitochondrial free radical theory of aging

1997 • 271 citations

Signalling and autophagy regulation in health, aging and disease

2006 • 243 citations

Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes

1989 • 236 citations

Structure of Atg5·Atg16, a Complex Essential for Autophagy

2006 • 232 citations

Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids.

1979 • 231 citations

Cyclophilin D as a Drug Target

2003 • 226 citations

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

1990 • 218 citations

The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

1995 • 207 citations

Class III phosphoinositide 3-kinase–Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes

2003 • 207 citations

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes

2003 • 197 citations

THE EFFECT OF AGE ON FORMATION AND ELIMINATION OF AUTOPHAGIC VACUOLES IN MOUSE HEPATOCYTES

1995 • 158 citations

Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question

2003 • 152 citations

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

2003 • 140 citations

Glycogen autophagy in glucose homeostasis

2006 • 135 citations

Peroxisome Biogenesis and Selective Degradation Converge at Pex14p

2001 • 109 citations

Autophagy: A cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically

2006 • 91 citations

Structural Aspects of Autophagy

1996 • 87 citations

Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death

2004 • 83 citations

Age-related changes in the skeletal muscle cells.

1988 • 81 citations

Membrane Origin for Autophagy

2006 • 79 citations

Genetic Dissection of the Permeability Transition Pore

2005 • 78 citations

Heat Shock Suppresses the Permeability Transition in Rat Liver Mitochondria

2003 • 76 citations

Ageing Changes in Mammalian Skeletal Muscle

1976 • 74 citations

Diversity of Signaling Controls of Macroautophagy in Mammalian Cells.

2002 • 71 citations

Studies on cellular autophagocytosis. A histochemical study on sequential alterations of mitochondria in the glucagon-induced autophagic vacuoles of rat liver.

1972 • 48 citations

Dephosphorylation of Bcl‐2 by protein phosphatase 2A results in apoptosis resistance

2004 • 40 citations

Genetic analysis of aging in Saccharomyces cerevisiae

1996 • 28 citations

Dephosphorylation of the Rieske iron–sulfur protein after induction of the mitochondrial permeability transition

2005 • 25 citations

Mechanism of autophagy in permeabilized hepatocytes: evidence for regulation by GTP binding proteins.

1996 • 10 citations

Mechanism of Autophagy in Permeabilized Hepatocytes

1996 • 9 citations