MMP Inhibition in Prostate Cancer

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Cancer statistics, 1998

1998 • 2,407 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The Endocrinology and Developmental Biology of the Prostate*

1987 • 1,047 citations

Carcinoma of the Prostate

1991 • 755 citations

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1991 • 522 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

Establishment and characterization of seven dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers

1986 • 412 citations

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

1997 • 403 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

THE RÔLE OF THE VERTEBRAL VEINS IN METASTATIC PROCESSES

1942 • 317 citations

Metastatic Model for Human Prostate Cancer Using Orthotopic Implantation in Nude Mice

1992 • 310 citations

Spread of prostatic cancer to bone

1983 • 289 citations

Steps in tumor metastasis: new concepts from intravital videomicroscopy

1995 • 268 citations

Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice.

1993 • 201 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

Prostate and Bone Fibroblasts Induce Human Prostate Cancer Growth in Vivo: Implications for Bidirectional Tumor-Stromal Cell Interaction in Prostate Carcinoma Growth and Metastasis

1992 • 188 citations

Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue.

1993 • 181 citations

In situ hybridization studies of metalloproteinases 2 and 9 and TIMP-1 and TIMP-2 expression in human prostate cancer.

1997 • 156 citations

Host modulation with tetracyclines and their chemically modified analogues.

1992 • 148 citations

Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis.

1998 • 139 citations

Suppression of Invasion by Inducible Expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in B 16-F10 Melanoma Cells

1992 • 137 citations

Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression.

1996 • 135 citations

Involvement of Urokinase and its Receptor in the Invasiveness of Human Prostatic Carcinoma Cell Lines

1991 • 132 citations

Proteases and Protease Inhibitors in Tumor Progression

1997 • 124 citations

Secretion of matrix metalloproteinases and their inhibitors (tissue inhibitor of metalloproteinases) by human prostate in explant cultures: reduced tissue inhibitor of metalloproteinase secretion by malignant tissues.

1993 • 119 citations

Matrix metalloproteinase inhibitors 1998

1998 • 115 citations

Taxol blocks processes essential for prostate tumor cell (PC-3 ML) invasion and metastases.

1992 • 93 citations

Orthotopic implantation of human prostate cancer cell lines: A clinically relevant animal model for metastatic prostate cancer

1997 • 87 citations

Origin and biology of cancer metastasis

1989 • 86 citations

Evolving strategies of cytotoxic chemotherapy for advanced prostate cancer

1997 • 85 citations

Effects of doxycycline on human prostate cancer cells in vitro

1998 • 82 citations

Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis.

1986 • 75 citations

Matrix metalloproteinases 1 and 3, tissue inhibitor of metalloproteinase-1 and the complex of metalloproteinase-1/tissue inhibitor in plasma of patients with prostate cancer

1997 • 75 citations

Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice.

1996 • 74 citations

Androgen Deprivation as a Strategy for Prostate Cancer Chemoprevention

1997 • 73 citations

The mitochondrial genetic system as a target for chemotherapy: Tetracyclines as cytostatics

1984 • 63 citations

Diversity of Melanoma Plasma Membrane Proteinases: Inhibition of Collagenolytic and Cytolytic Activities by Minocycline<xref ref-type="fn" rid="FN2">2</xref>

1985 • 59 citations

Patterns of metastasis by the human prostate cancer cell line PC‐3 in athymic nude mice

1989 • 51 citations

Increased matrix metalloproteinase-9 secretion in short-term tissue cultures of prostatic tumor cells

1996 • 51 citations

Matrilysin Expression in the Involuting Rat Ventral Prostate

1996 • 49 citations

Inhibition of Tumor Angiogenesis^a

1994 • 45 citations

IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression.

1997 • 45 citations

Enhancement of radiation response of prostatic carcinoma by taxol: therapeutic potential for late-stage malignancy.

1995 • 43 citations

Prostatic tumor (R3327) skeletal metastasis

1990 • 41 citations

Prostatic microcarcinomas in relation to cancer origin and the evolution to clinical cancer

1993 • 34 citations

Clinical Trials of a Low Molecular Weight Matrix Metalloproteinase Inhibitor in Cancer

1994 • 33 citations

Potential Application of a Chemically Modified Non-Antimicrobial Tetracycline (CMT-3) Against Metastatic Prostate Cancer

1998 • 30 citations

Acid-activated insulin-like growth factor binding protein protease activity of Cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma

1997 • 29 citations

Medical approaches in the management of prostatic disease

1997 • 26 citations

The Management of Hormone Refractory Prostate Cancer

1996 • 26 citations

HPLC determination of a chemically modified nonantimicrobial tetracycline: Biological implications

1992 • 25 citations

RECENT ADVANCES IN THE MEDICAL MANAGEMENT OF PROSTATE CANCER

1996 • 24 citations

Endocrine Therapy for Prostate Cancer: Recent Developments and Current Status

1993 • 19 citations

Analysis of the TIMP‐1/FIB‐CL Complex^a

1994 • 9 citations

Current treatment of advanced prostate cancer.

1997 • 9 citations

Mini review: Proteases and invasion in human prostate epithelial cell lines: Implications in prostate cancer prevention and intervention

1995 • 7 citations