Back to search

Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms

Data up to Jan 2025

Published2000
Citations215
References71

Total Citations Per Year

Abstract

References (71)

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

Inflammation and Matrix Metalloproteinases in the Enlarging Abdominal Aortic Aneurysm

1995 • 671 citations

Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms

1998 • 666 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

1997 • 493 citations

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.

1990 • 459 citations

Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms.

1998 • 455 citations

Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.

1995 • 452 citations

Mechanisms for pro matrix metalloproteinase activation

1999 • 436 citations

Minocycline reduces gingival collagenolytic activity during diabetes

1983 • 415 citations

Clinical Pharmacokinetics of Doxycycline and Minocycline

1988 • 329 citations

Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: Preservation of aortic elastin associated with suppressed production of 92 kD gelatinase

1996 • 323 citations

A rapid and versatile method to synthesize internal standards for competitive PCR

1993 • 318 citations

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

1987 • 307 citations

Role of Matrix Metalloproteinases in Abdominal Aortic Aneurysmsa

1996 • 304 citations

Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta

1997 • 297 citations

Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model.

1998 • 294 citations

Elastin degradation in abdominal aortic aneurysms

1987 • 292 citations

A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis

1997 • 283 citations

Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms

1998 • 253 citations

Failure of Elastin or Collagen as Possible Critical Connective Tissue Alterations Underlying Aneurysmal Dilatation

1994 • 232 citations

Inhibition of MMP Synthesis by Doxycycline and Chemically Modified Tetracyclines (CMTs) in Human Endothelial Cells

1998 • 223 citations

Size Matters

1997 • 222 citations

The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases

1996 • 216 citations

Cell surface activation of progelatinase A (proMMP-2) and cell migration

1998 • 201 citations

Metalloproteinases in degenerative aortic disease

1991 • 196 citations

Pharmacologic suppression of experimental abdominal aortic aneurysms: A comparison of doxycycline and four chemically modified tetracyclines

1998 • 190 citations

MMP Inhibition in Abdominal Aortic Aneurysms: Rationale for a Prospective Randomized Clinical Trial

1999 • 188 citations

Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm.

1994 • 185 citations

Regulation of Matrix Metalloproteinase Gene Expression

1998 • 178 citations

Increased plasma levels of metalloproteinase-9 are associated with abdominal aortic aneurysms

1999 • 176 citations

Effects of Tetracyclines on Neutrophil, Gingival, and Salivary Collagenases

1994 • 172 citations

In Situ Localization and Quantification of mRNA for 92-kD Type IV Collagenase and Its Inhibitor in Aneurysmal, Occlusive, and Normal Aorta

1995 • 161 citations

Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms.

1991 • 152 citations

Host modulation with tetracyclines and their chemically modified analogues.

1992 • 148 citations

Doxycycline and Chemically Modified Tetracyclines Inhibit Gelatinase A (MMP‐2) Gene Expression in Human Skin Keratinocytes

1994 • 141 citations

Aortic Aneurysm Formation

1998 • 137 citations

Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem

1996 • 130 citations

The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms

1999 • 129 citations

Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease

1998 • 127 citations

Demonstration of Interstitial Collagenase in Abdominal Aortic Aneurysm Disease

1993 • 125 citations

In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta

1995 • 122 citations

Expression of Matrix Metalloproteinases and TIMPs in Human Abdominal Aortic Aneurysms

1998 • 121 citations

Differential patterns of response to doxycycline and transforming growth factor ?1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes

1999 • 111 citations

A Non‐Antimicrobial Tetracycline Inhibits Gingival Matrix Metalloproteinases and Bone Loss in Porphyromonas gingivalis‐induced Periodontitis in Ratsa

1994 • 110 citations

Indomethacin Prevents Elastase-Induced Abdominal Aortic Aneurysms in the Rat

1996 • 108 citations

Safety and Efficacy of Sub-Antimicrobial-Dose Doxycycline Therapy in Patients with Adult Periodontitis

1998 • 94 citations

The “Cyclic” Regimen of Low‐Dose Doxycycline for Adult Periodontitis: A Preliminary Study

1996 • 91 citations

Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage.

1998 • 89 citations

Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase

1999 • 89 citations

Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity

1996 • 86 citations

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)

1999 • 83 citations

The Cause and management of aneurysms

1990 • 83 citations

Doxycycline Revisited

1997 • 81 citations

12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.

1986 • 74 citations

Histochemistry of Aortic Elastin in Patients With Nonspecific Abdominal Aortic Aneurysmal Disease

1988 • 73 citations

Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline

1985 • 71 citations

Anti-CD 18 monoclonal antibody slows experimental aortic aneurysm expansion

1996 • 63 citations

Inflammatory Aspects of Experimental Aneurysms

1996 • 63 citations

Characterization of an Elastase from Aneurysmal Aorta Which Degrades Intact Aortic Elastin

1992 • 60 citations

Connective tissue proteinases and inhibitors in abdominal aortic aneurysms

1993 • 52 citations

How do Tetracyclines Work?

1998 • 49 citations

Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis

1999 • 47 citations

Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.

1992 • 36 citations

THE FORMATION OF ANEURYSMS

1952 • 29 citations

Therapeutic Potential of Tetracycline Derivatives to Suppress the Growth of Abdominal Aortic Aneurysms

1998 • 29 citations

Suppression of Experimental Aneurysmal Degeneration with Chemically Modified Tetracycline Derivativesa

1996 • 18 citations

The in Vivo Effect of Doxycycline Treatment on Matrix Metalloproteinases in Reactive Arthritisa

1994 • 13 citations

Plaque Modification with Tetracycline: Enhanced Tissue Ablation with the Excimer Laser

1990 • 4 citations

Chronic Inflammation, Matrix Metalloproteinases, and Medial Smooth Muscle Cell Apoptosis: Interrelated Factors in the Progression of Abdominal Aortic Aneurysms

1998 • 2 citations

DOXYCYCLINE IN HUMAN OVIDUCT MUCOSA AND PLASMA 24–30 HOURS AFTER AN ORAL DOSE OF 100 MG

1985 • 2 citations

Cited By (0)

Loading...
Preoperative treatment with doxycycline reduces aortic wall expression and activation of… (2000) – Journal of Vascular Surgery | Metascience Observatory Explorer