Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms
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References (71)
Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.
1990 • 1,484 citations
Inflammation and Matrix Metalloproteinases in the Enlarging Abdominal Aortic Aneurysm
1995 • 671 citations
Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms
1998 • 666 citations
Human 92- and 72-kilodalton type IV collagenases are elastases.
1991 • 550 citations
Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells
1997 • 493 citations
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
1990 • 459 citations
Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms.
1998 • 455 citations
Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.
1995 • 452 citations
Mechanisms for pro matrix metalloproteinase activation
1999 • 436 citations
Minocycline reduces gingival collagenolytic activity during diabetes
1983 • 415 citations
Clinical Pharmacokinetics of Doxycycline and Minocycline
1988 • 329 citations
Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: Preservation of aortic elastin associated with suppressed production of 92 kD gelatinase
1996 • 323 citations
A rapid and versatile method to synthesize internal standards for competitive PCR
1993 • 318 citations
A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity
1987 • 307 citations
Role of Matrix Metalloproteinases in Abdominal Aortic Aneurysmsa
1996 • 304 citations
Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta
1997 • 297 citations
Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model.
1998 • 294 citations
Elastin degradation in abdominal aortic aneurysms
1987 • 292 citations
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis
1997 • 283 citations
Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms
1998 • 253 citations
Failure of Elastin or Collagen as Possible Critical Connective Tissue Alterations Underlying Aneurysmal Dilatation
1994 • 232 citations
Inhibition of MMP Synthesis by Doxycycline and Chemically Modified Tetracyclines (CMTs) in Human Endothelial Cells
1998 • 223 citations
Size Matters
1997 • 222 citations
The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases
1996 • 216 citations
Cell surface activation of progelatinase A (proMMP-2) and cell migration
1998 • 201 citations
Metalloproteinases in degenerative aortic disease
1991 • 196 citations
Pharmacologic suppression of experimental abdominal aortic aneurysms: A comparison of doxycycline and four chemically modified tetracyclines
1998 • 190 citations
MMP Inhibition in Abdominal Aortic Aneurysms: Rationale for a Prospective Randomized Clinical Trial
1999 • 188 citations
Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm.
1994 • 185 citations
Regulation of Matrix Metalloproteinase Gene Expression
1998 • 178 citations
Increased plasma levels of metalloproteinase-9 are associated with abdominal aortic aneurysms
1999 • 176 citations
Effects of Tetracyclines on Neutrophil, Gingival, and Salivary Collagenases
1994 • 172 citations
In Situ Localization and Quantification of mRNA for 92-kD Type IV Collagenase and Its Inhibitor in Aneurysmal, Occlusive, and Normal Aorta
1995 • 161 citations
Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms.
1991 • 152 citations
Host modulation with tetracyclines and their chemically modified analogues.
1992 • 148 citations
Doxycycline and Chemically Modified Tetracyclines Inhibit Gelatinase A (MMP‐2) Gene Expression in Human Skin Keratinocytes
1994 • 141 citations
Aortic Aneurysm Formation
1998 • 137 citations
Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem
1996 • 130 citations
The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms
1999 • 129 citations
Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease
1998 • 127 citations
Demonstration of Interstitial Collagenase in Abdominal Aortic Aneurysm Disease
1993 • 125 citations
In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta
1995 • 122 citations
Expression of Matrix Metalloproteinases and TIMPs in Human Abdominal Aortic Aneurysms
1998 • 121 citations
Differential patterns of response to doxycycline and transforming growth factor ?1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes
1999 • 111 citations
A Non‐Antimicrobial Tetracycline Inhibits Gingival Matrix Metalloproteinases and Bone Loss in Porphyromonas gingivalis‐induced Periodontitis in Ratsa
1994 • 110 citations
Indomethacin Prevents Elastase-Induced Abdominal Aortic Aneurysms in the Rat
1996 • 108 citations
Safety and Efficacy of Sub-Antimicrobial-Dose Doxycycline Therapy in Patients with Adult Periodontitis
1998 • 94 citations
The “Cyclic” Regimen of Low‐Dose Doxycycline for Adult Periodontitis: A Preliminary Study
1996 • 91 citations
Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage.
1998 • 89 citations
Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase
1999 • 89 citations
Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity
1996 • 86 citations
Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)
1999 • 83 citations
The Cause and management of aneurysms
1990 • 83 citations
Doxycycline Revisited
1997 • 81 citations
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
1986 • 74 citations
Histochemistry of Aortic Elastin in Patients With Nonspecific Abdominal Aortic Aneurysmal Disease
1988 • 73 citations
Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline
1985 • 71 citations
Anti-CD 18 monoclonal antibody slows experimental aortic aneurysm expansion
1996 • 63 citations
Inflammatory Aspects of Experimental Aneurysms
1996 • 63 citations
Characterization of an Elastase from Aneurysmal Aorta Which Degrades Intact Aortic Elastin
1992 • 60 citations
Connective tissue proteinases and inhibitors in abdominal aortic aneurysms
1993 • 52 citations
How do Tetracyclines Work?
1998 • 49 citations
Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis
1999 • 47 citations
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
1992 • 36 citations
THE FORMATION OF ANEURYSMS
1952 • 29 citations
Therapeutic Potential of Tetracycline Derivatives to Suppress the Growth of Abdominal Aortic Aneurysms
1998 • 29 citations
Suppression of Experimental Aneurysmal Degeneration with Chemically Modified Tetracycline Derivativesa
1996 • 18 citations
The in Vivo Effect of Doxycycline Treatment on Matrix Metalloproteinases in Reactive Arthritisa
1994 • 13 citations
Plaque Modification with Tetracycline: Enhanced Tissue Ablation with the Excimer Laser
1990 • 4 citations
Chronic Inflammation, Matrix Metalloproteinases, and Medial Smooth Muscle Cell Apoptosis: Interrelated Factors in the Progression of Abdominal Aortic Aneurysms
1998 • 2 citations
DOXYCYCLINE IN HUMAN OVIDUCT MUCOSA AND PLASMA 24–30 HOURS AFTER AN ORAL DOSE OF 100 MG
1985 • 2 citations