Inhibition of Matrix Metalloproteinase 9 Activation by a Specific Monoclonal Antibody

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

[1] Preparation of monoclonal antibodies: Strategies and procedures

1981 • 1,787 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Production of monoclonal antibodies: Strategy and tactics

1980 • 1,594 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2

1991 • 227 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens

1982 • 203 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells

1992 • 191 citations

Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells.

1986 • 172 citations

A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts.

1979 • 157 citations

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

1992 • 153 citations

Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells.

1990 • 151 citations

Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex

1993 • 138 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen.

1990 • 118 citations

Gelatinases of metastatic cell lines of murine colonic carcinoma as detected by substrate-gel electrophoresis

1988 • 117 citations

Gelatinase (type iv collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low M r forms

1989 • 87 citations

Modulation of type‐iv collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type‐iv collagenase

1990 • 76 citations

[5] Somatic cell genetic analysis of myelomas and hybridomas

1987 • 15 citations