Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

2009 • 3,258 citations

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Statins and the risk of dementia

2000 • 1,741 citations

The Role of Apolipoprotein E in Alzheimer's Disease

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Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

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Apolipoprotein E polymorphism and Alzheimer's disease

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Clinical trial of indomethacin in Alzheimer's disease

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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

2012 • 982 citations

2010 Alzheimer's disease facts and figures

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Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

2011 • 597 citations

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

1995 • 596 citations

Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury

1999 • 447 citations

Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism

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Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

2007 • 376 citations

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

2004 • 370 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

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Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele

1997 • 321 citations

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1996 • 302 citations

Demography of longevity: past, present, and future trends

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Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

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Genetics of the apolipoprotein E system in man.

1980 • 268 citations

HumanAPOEIsoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice

2009 • 255 citations

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

2007 • 230 citations

Apolipoprotein E receptors: linking brain development and alzheimer's disease

2000 • 218 citations

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease

1995 • 215 citations

Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease

2012 • 205 citations

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

2013 • 196 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆

1999 • 194 citations

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

2012 • 194 citations

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

1998 • 191 citations

The Women's Health Initiative Memory Study: findings and implications for treatment

2005 • 167 citations

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

2003 • 161 citations

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease

2004 • 160 citations

APOE and cholesterol homeostasis in Alzheimer's disease

2010 • 158 citations

Functions of lipoprotein receptors in neurons

2004 • 147 citations

Plasma apolipoprotein E and Alzheimer disease risk

2011 • 146 citations

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

1997 • 142 citations

Apolipoprotein E controls the risk and age at onset of Parkinson disease

2004 • 142 citations

Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

2007 • 136 citations

Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation

2000 • 135 citations

Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

1999 • 134 citations

Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans

1995 • 126 citations

A study of French centenarians: are ACE and APOE associated with longevity?

2001 • 124 citations

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

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Reduced levels of human apoE4 protein in an animal model of cognitive impairment

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Amyloid β‐Protein, APOE Genotype and Head Injury

1996 • 100 citations

Cholinesterases and Cholinesterase Inhibitors

2008 • 100 citations

Increase in plasma cholesteryl ester transfer protein during probucol treatment. Relation to changes in high density lipoprotein composition.

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The Women's Health Initiative Memory Study: findings and implications for treatment

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Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice

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Longevity and the 2 Allele of Apolipoprotein E: The Finnish Centenarians Study

2001 • 78 citations

Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

1999 • 73 citations

Apoliprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate

2000 • 70 citations

Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task

2002 • 65 citations

The cholesterol-lowering drug Probucol increases apolipoprotein e production in the hippocampus of aged rats: implications for Alzheimer’s disease

2003 • 64 citations

CHOLESTEROL TRANSPORT AND SYNTHESIS IN SPORADIC ALZHEIMER'S DISEASE

2005 • 54 citations

Apolipoprotein E represents a potent gene‐based therapeutic target for the treatment of sporadic Alzheimer's disease

2008 • 50 citations

Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer’s disease patients and centenarians

2003 • 49 citations

Apoliprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate

2000 • 49 citations

Differential neurotrophic effects of apolipoprotein E in aged transgenic mice

1999 • 46 citations

Relationship between serum pseudocholinesterase and triglycerides in experimentally induced diabetes mellitus in rats

1991 • 44 citations

Evolution of the human lifespan, past, present, and future: phases in the evolution of human life expectancy in relation to the inflammatory load.

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Biochemical and cognitive studies of apolipoprotein-E-deficient mice

1996 • 43 citations

Adipose tissue cholesteryl ester transfer protein mRNA in response to probucol treatment: cholesterol and species dependence

1993 • 43 citations

A Protective Role of the Low Density Lipoprotein Receptor-related Protein against Amyloid β-Protein Toxicity

2000 • 42 citations

Effect of apolipoprotein E deficiency on reactive sprouting in the dentate gyrus of the hippocampus following entorhinal cortex lesion: role of the astroglial response

2005 • 39 citations

Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer’s disease

2002 • 36 citations

Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice

2000 • 31 citations

Probucol Suppresses Enterocytic Accumulation of Amyloid‐β Induced by Saturated Fat and Cholesterol Feeding

2011 • 25 citations

Apolipoprotein E Mutants, Hyperlipidemia and Arteriosclerosis

1985 • 25 citations

Non‐steroidal anti‐inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein

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The effects of apolipoprotein e deficiency on braincholinergic neurons

1998 • 17 citations

Apolipoprotein E: A Novel Therapeutic Target for the Treatment of Alzheimer’s Disease

2002 • 15 citations

Experience with probucol in the treatment of hypercholesterolemia.

1982 • 3 citations