The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

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2006 • 2,741 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

2004 • 1,184 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 • 1,058 citations

Brain Cholesterol: Long Secret Life Behind a Barrier

2004 • 935 citations

Liver X receptors as integrators of metabolic and inflammatory signaling

2006 • 906 citations

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

2006 • 668 citations

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

2004 • 530 citations

ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition

2004 • 421 citations

Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

2003 • 351 citations

Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

2005 • 331 citations

Cholesterol in Alzheimer's disease

2005 • 325 citations

Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

2005 • 304 citations

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

2001 • 301 citations

Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease

2002 • 270 citations

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

2002 • 267 citations

Cholesterol and the Biology of Alzheimer's Disease

2004 • 267 citations

The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

2004 • 257 citations

The hippocampus and contextual memory retrieval in Pavlovian conditioning

2000 • 251 citations

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

2003 • 235 citations

The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease

2005 • 224 citations

Acute γ-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease

2005 • 217 citations

Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

2002 • 196 citations

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

2003 • 173 citations

Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels

2002 • 155 citations

Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

2004 • 131 citations

The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice

2005 • 129 citations

The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo

2006 • 97 citations

ApoE and Aβ1–42 Interactions: Effects of Isoform and Conformation on Structure and Function

2004 • 95 citations

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42

2004 • 83 citations

Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue

2004 • 73 citations

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism

2004 • 61 citations

Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

2002 • 48 citations

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide

2005 • 42 citations