Apolipoprotein E Mutants, Hyperlipidemia and Arteriosclerosis

Principles and Practice of Medical Genetics

1984 • 769 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.

1982 • 674 citations

Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

1977 • 654 citations

CYSTIC FIBROSIS

1974 • 589 citations

Polymorphism of apolipoprotein E

1979 • 405 citations

Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.

1982 • 349 citations

Familial hyperlipoproteinemia type III: Deficiency of a specific apolipoprotein (APO E‐III) in the very‐low‐density lipoproteins

1975 • 342 citations

Human apolipoprotein E isoprotein subclasses are genetically determined.

1981 • 341 citations

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

1981 • 316 citations

Gel isoelectric focusing method for specific diagnosis of familial hyperlipoproteinemia type 3.

1979 • 268 citations

Apolipoprotein E phenotypes and hyperlipidemia

1984 • 246 citations

Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia

1977 • 241 citations

Polymorphism of Apolipoprotein E

1980 • 212 citations

Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia.

1980 • 191 citations

Type III Hyperlipoproteinemia: Defective Metabolism of an Abnormal Apolipoprotein E

1981 • 183 citations

Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2

1982 • 177 citations

Apolipoprotein E phenotypes in patients with myocardial infarction

1984 • 156 citations

Genetic control of human apolipoprotein E polymorphism: Comparison of one-and two-dimensional techniques of isoprotein analysis

1982 • 153 citations

Identification and DNA sequence of a human apolipoprotein E cDNA clone.

1982 • 101 citations

Identical Structural and Receptor Binding Defects in Apolipoprotein E2 in Hypo-, Normo-, and Hypercholesterolemic Dysbetalipoproteinemia

1983 • 92 citations

PHENOTYPE STUDY OF APOLIPOPROTEIN E ISOFORMS IN HYPERLIPOPROTEINAEMIC PATIENTS

1982 • 92 citations

Genetic variation in human apolipoprotein E

1982 • 90 citations

Genetic transmission of isoapolipoprotein E phenotypes in a large kindred: Relationship to dysbetalipoproteinemia and hyperlipidemia

1981 • 78 citations

Type III hyperlipoproteinemia: development of a VLDL ApoE gel isoelectric focusing technique and application in family studies.

1979 • 61 citations

Studies on the metabolic defect in Broad‐ß disease (hyperlipoproteinaemia type III)

1977 • 43 citations

Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

1984 • 38 citations

Functionally inactive apolipoprotein E₃ in a type III hyperlipoproteinaemic patient

1984 • 31 citations

Apolipoprotein E

1982 • 22 citations

Familial Hyperlipoproteinemia Type III

1969 • 21 citations

Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III).

1982 • 16 citations