Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Promoter Attenuation in Gene Therapy: Interferon-γand Tumor Necrosis Factor-αInhibit Transgene Expression

1997 • 317 citations

Animal models

1994 • 276 citations

High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes.

1995 • 266 citations

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

1996 • 244 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man.

1990 • 145 citations

Accumulation of bromodeoxyuridine‐labeled cells in central and peripheral lymphoid organs: minimal estimates of prodution and turnover rates of mature lymphocytes

1990 • 128 citations

Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells.

1994 • 112 citations

Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.

1994 • 95 citations

Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis

1992 • 91 citations

Scaffold Attachment Region-Mediated Enhancement of Retroviral Vector Expression in Primary T Cells

1998 • 88 citations

Gene transfer through the blood–nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis

1995 • 78 citations

Selective localisation of neuro-specific T lymphocytes in the central nervous system

1992 • 70 citations

Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis.

1995 • 66 citations

Apoptosis in brain-specific autoimmune disease

1995 • 64 citations

Lymphocyte apoptosis: induction by gene transfer techniques

1997 • 62 citations

High-efficiency retroviral vector mediated gene transfer into human peripheral blood CD4+ T lymphocytes.

1996 • 61 citations

T Cell Activation Modulates Retrovirus-Mediated Gene Expression

1998 • 52 citations

Green fluorescent protein as a reporter of gene expression in transgenic mice

1997 • 47 citations

Comparison of CNS homing pattern among murine TH cell lines responsive to myelin basic protein

1992 • 16 citations

Immune regulation in self tolerance: functional elimination of a self‐reactive, counterregulatory CD8⁺ T lymphocyte circuit by neonatal transfer of encephalitogenic CD4⁺ T cells lines

1992 • 14 citations