Temporal Lineage Tracing of Aire-Expressing Cells Reveals a Requirement for Aire in Their Maturation Program

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

1997 • 958 citations

Aire

2009 • 533 citations

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2007 • 463 citations

Faithful activation of an extra‐bright red fluorescent protein in “knock‐in” Cre‐reporter mice ideally suited for lineage tracing studies

2006 • 462 citations

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

2007 • 367 citations

A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre‐mediated recombination

2000 • 352 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Aire's Partners in the Molecular Control of Immunological Tolerance

2010 • 314 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

The autoimmune regulator PHD finger binds to non‐methylated histone H3K4 to activate gene expression

2008 • 226 citations

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

2008 • 212 citations

Generating intrathymic microenvironments to establish T-cell tolerance

2007 • 184 citations

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

2009 • 163 citations

AIRE Recruits P-TEFb for Transcriptional Elongation of Target Genes in Medullary Thymic Epithelial Cells

2007 • 151 citations

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

2010 • 140 citations

Lineage Tracing and Cell Ablation Identify a Post-Aire-Expressing Thymic Epithelial Cell Population

2013 • 130 citations

Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype

2009 • 129 citations

Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

2007 • 126 citations

Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens

2012 • 103 citations

Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation

2008 • 71 citations

Developmental pathway of CD4⁺CD8⁻medullary thymocytes during mouse ontogeny and its defect inAire^−/−mice

2007 • 64 citations

Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

2010 • 43 citations