Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells

2008 • 468 citations

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

2008 • 464 citations

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2007 • 463 citations

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

2007 • 367 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Aire's Partners in the Molecular Control of Immunological Tolerance

2010 • 314 citations

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

2008 • 224 citations

A Defect of Regulatory T Cells in Patients with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

2007 • 217 citations

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

2008 • 212 citations

Central tolerance: good but imperfect

2006 • 196 citations

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells

2007 • 142 citations

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

2010 • 140 citations

Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

2010 • 136 citations

Aire and T cell development

2010 • 132 citations

Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype

2009 • 129 citations

Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity

2005 • 127 citations

Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

2007 • 126 citations

A Specific Anti-Aire Antibody Reveals Aire Expression Is Restricted to Medullary Thymic Epithelial Cells and Not Expressed in Periphery

2008 • 105 citations

Modulation of Aire regulates the expression of tissue-restricted antigens

2007 • 99 citations

Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.

1996 • 96 citations

Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes

2009 • 86 citations

Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation

2008 • 71 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

Developmental pathway of CD4⁺CD8⁻medullary thymocytes during mouse ontogeny and its defect inAire^−/−mice

2007 • 64 citations

Corticosteroids Regulate Epithelial Cell Differentiation and Hassall Body Formation in the Human Thymus

2004 • 58 citations

Aire-Dependent Thymic Expression of Desmoglein 3, the Autoantigen in Pemphigus Vulgaris, and Its Role in T-Cell Tolerance

2010 • 49 citations

Novel insights into the function of the thymic Hassall's bodies.

2000 • 43 citations

Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

2010 • 43 citations

Autoimmune regulator (AIRE)-deficient CD8⁺CD28^lowregulatory T lymphocytes fail to control experimental colitis

2011 • 19 citations

Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)‐deficient mice

2009 • 13 citations

Immunohistochemical staining of transgenic beta-galactosidase in burned skin is a better indicator of transfection efficiency than histochemical techniques

2006 • 9 citations

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

2013 • 7 citations

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

2008 • 7 citations