Heat shock proteins transfer peptides during antigen processing and CTL priming

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.

1960 • 736 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Heat shock protein 70-associated peptides elicit specific cancer immunity.

1993 • 631 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Biological role and regulation of the universally conserved heat shock proteins.

1991 • 319 citations

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

1986 • 295 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

On the nature of peptides involved in T cell alloreactivity.

1991 • 220 citations

The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens.

1989 • 215 citations

Role of the Major Histocompatibility Complex Class I Antigens in Tumor Growth and Metastasis

1988 • 201 citations

The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules

1991 • 187 citations

Stress-Induced Proteins in Immune Response to Cancer

1991 • 179 citations

Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway

1991 • 171 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas.

1992 • 155 citations

Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene.

1970 • 144 citations

Which came first, MHC class I or class II?

1991 • 132 citations

Individually distinct transplantation antigens of chemically induced mouse tumors

1988 • 113 citations

Identification of a peptide binding protein that plays a role in antigen presentation.

1987 • 112 citations

Antigenic Specificity of Benzo[a]pyrene-Induced Sarcomas2

1964 • 107 citations

Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation?

1991 • 105 citations

A Certain Symmetry : Histocompatibility Antigens compared with Immunocyte Receptors

1970 • 104 citations

The serologically unique cell surface antigen of zajdela ascitic hepatoma is also its tumor‐associated transplantation antigen

1984 • 102 citations

The LMP antigens: A stable MHC-controlled multisubunit protein complex

1986 • 93 citations

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

1991 • 89 citations

H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes.

1980 • 86 citations

Expression of a shared tumor-specific antigen by two chemically induced BALB/c sarcomas.

1987 • 79 citations

Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression

1991 • 68 citations

5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.

1987 • 68 citations

Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited

1993 • 63 citations

Molecular mechanisms by which adenoviruses counteract antiviral immune defenses.

1990 • 62 citations

Molecular heterogeneity of tumor rejection antigen/heat shock protein GP96

1995 • 55 citations

Relationship of X Chromosome Dosage Compensation to Intracellular Self/Not-self Discrimination: A Resolution of Muller's Paradox?

1994 • 25 citations

Characterization of the Mouse 84-kD Heat Shock Protein Gene Family

1990 • 21 citations

The Heat-shock Response and the Molecular Basis of Genetic Dominance

1994 • 17 citations