P-Glycoprotein Limits the Brain Penetration of Nonsedating but not Sedating H1-Antagonists

Pharmacokinetics

1982 • 3,815 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The multidrug resistance protein family

1999 • 654 citations

Rational use of in vitro P-glycoprotein assays in drug discovery.

2001 • 637 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1999 • 457 citations

Stimulation of P‐glycoprotein‐mediated drug transport by prazosin and progesterone

1999 • 299 citations

Astemizole

1984 • 258 citations

Grapefruit juice activates P-glycoprotein-mediated drug transport.

1999 • 195 citations

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.

2001 • 195 citations

Pharmacological insights from P-glycoprotein knockout mice.

1998 • 147 citations

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

1997 • 140 citations

Loratadine

1989 • 134 citations

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice.

1999 • 113 citations

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine

1996 • 103 citations

Retroviral Transfection of Madin-Darby Canine Kidney Cells with Human MDR1 Results in a Major Increase in Globotriaosylceramide and 105- to 106-Fold Increased Cell Sensitivity to Verocytotoxin

2000 • 100 citations

H1-receptor antagonists: safety issues

1999 • 92 citations

Cardiotoxicity of new antihistamines and cisapride

2002 • 89 citations

Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation

1999 • 82 citations

Drug-stimulated ATPase activity of the human P-glycoprotein

1995 • 80 citations

Affinity for the P-Glycoprotein Efflux Pump at the Blood-Brain Barrier May Explain the Lack of CNS Side-Effects of Modern Antihistamines

2001 • 77 citations

Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.

2001 • 68 citations

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

1999 • 66 citations

New findings in pharmacological effects induced by antihistamines: from PET studies to knock‐out mice

1999 • 63 citations

Altered disposition and antinociception of [D-penicillamine(2,5)] enkephalin in mdr1a-gene-deficient mice.

1998 • 58 citations

Terfenadine (seldane®): A new drug for restoring sensitivity to multidrug resistant cancer cells

1993 • 53 citations

Loratadine: Multiple‐Dose Pharmacokinetics

1987 • 49 citations

Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.

2001 • 48 citations

Factors involved in the absence of sedative effects by thesecond‐generation antihistamines

2000 • 38 citations

Why are non-sedating antihistamines non-sedating?

1999 • 35 citations

Animal models of asthma and chronic bronchitis

1999 • 32 citations

The use of transgenic mice in pharmacokinetic and pharmacodynamic studies

2001 • 10 citations