Grapefruit juice activates P-glycoprotein-mediated drug transport.

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

1997 • 620 citations

Interaction of citrus juices with felodipine and nifedipine

1991 • 595 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

1997 • 450 citations

Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics†

1998 • 418 citations

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1993 • 365 citations

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

1995 • 349 citations

Active secretion and enterocytic drug metabolism barriers to drug absorption

1996 • 310 citations

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

1997 • 303 citations

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1999 • 292 citations

Drug Interactions with Grapefruit Juice

1998 • 251 citations

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

1998 • 213 citations

Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery

1996 • 194 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.

1992 • 177 citations

Inhibition of Vinblastine Efflux Mediated by P-Glycoprotein by Grapefruit Juice Components in Caco-2 Cells.

1998 • 172 citations

Modulation of adriamycin® accumulation and efflux by flavonoids in HCT-15 colon cells

1994 • 171 citations

THE PHARMACOLOGICAL ROLE OF P-GLYCOPROTEIN IN THE INTESTINAL EPITHELIUM

1998 • 130 citations

Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells.

1993 • 106 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Grapefruit juice—terfenadine single-dose interaction: Magnitude, mechanism, and relevance*

1997 • 68 citations

Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17β-estradiol

1995 • 43 citations

Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.

1998 • 40 citations