Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

Octanol-water partition coefficients: Fundamentals and physical chemistry

1997 • 649 citations

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

1997 • 449 citations

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

1999 • 198 citations

Development of anIn SituMouse Brain Perfusion Model and its Application tomdr1aP-Glycoprotein-Deficient Mice

2000 • 196 citations

Complete in vivo reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomography

1998 • 182 citations

Interaction of structurally diverse pesticides with thehuman MDR1 gene product P-glycoprotein

1996 • 172 citations

Clinical Studies with Modulators of Multidrug Resistance

1995 • 163 citations

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

1997 • 140 citations

Gender Differences in Regional Cerebral Blood Flow

1990 • 129 citations

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

1997 • 123 citations

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.

1996 • 122 citations

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine.

1987 • 115 citations

Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System

1996 • 112 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

1996 • 101 citations

Morphine antinociception is enhanced in mdr1a gene-deficient mice.

2000 • 99 citations

17 beta-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier

1997 • 94 citations

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

1994 • 82 citations

Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice.

2001 • 79 citations

Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum

1998 • 73 citations

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism.

1995 • 72 citations

Assessment of Stereoselectivity of Trimethylphenylalanine Analogues of δ‐Opioid [D‐Pen²,D‐Pen⁵]‐Enkephalin

2000 • 41 citations

Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier.

1999 • 41 citations

Intravenous verapamil kinetics in rats: Marked arteriovenous concentration difference and comparison with humans

1993 • 32 citations

Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment

1998 • 18 citations

Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.

1996 • 16 citations

Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins

1995 • 12 citations

Increased Plasma Binding and Decreased Blood Cell Binding of Quinidine in Blood from Anuric Rats

1977 • 7 citations