The role of the IGF‐I receptor in the growth and transformation of mammalian cells

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells.

1990 • 385 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.

1987 • 309 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

1988 • 235 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1992 • 214 citations

RETRACTED ARTICLE: Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells

1992 • 183 citations

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

1992 • 183 citations

Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

1992 • 180 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Cell cycle and growth control.

1993 • 110 citations

Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent.

1989 • 103 citations

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

1993 • 100 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines.

1993 • 98 citations

Somatomedin: Physiological Control and Effects on Cell Proliferation

1981 • 91 citations

The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells.

1992 • 82 citations

Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts.

1991 • 80 citations

Alterations in the Responsiveness of Senescent Cells to Growth Factors

1989 • 79 citations

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1991 • 64 citations

Cytokines and cell growth control.

1991 • 64 citations

Cell cycle and growth control

1994 • 58 citations

The role of the IGF‐1 receptor in the stimulation of cells by short pulses of growth factors

1993 • 21 citations