Eukaryotic Nucleases and mRNA Turnover

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Capping of eucaryotic mRNAs

1976 • 1,141 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

5′-Terminal structure and mRNA stability

1977 • 542 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

5'-terminal cap structure in eucaryotic messenger ribonucleic acids

1980 • 463 citations

SnRNAs, SnRNPs, and RNA Processing

1982 • 458 citations

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

1990 • 409 citations

A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability.

1987 • 401 citations

The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro.

1989 • 373 citations

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

1981 • 357 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.

1988 • 324 citations

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

1981 • 321 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

1979 • 245 citations

mRNA cap binding proteins: essential factors for initiating translation

1985 • 242 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

1991 • 222 citations

Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast

1992 • 212 citations

Translation Initiation and Ribosomal Biogenesis: Involvement of a Putative rRNA Helicase and RPL46

1990 • 204 citations

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.

1985 • 203 citations

5'-terminal cap structure in eucaryotic messenger ribonucleic acids.

1980 • 189 citations

Purification and characterization of a Saccharomyces cerevisiae exoribonuclease which yields 5'-mononucleotides by a 5' leads to 3' mode of hydrolysis.

1980 • 188 citations

H4 histone messenger RNA decay in cell-free extracts initiates at or near the 3′ terminus and proceeds 3′ to 5′

1986 • 179 citations

Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.

1977 • 179 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

The role of poly(A) in the translation and stability of mRNA

1990 • 154 citations

Disruption of the gene XRN1, coding for a 5′→3′ exoribonuclease, restricts yeast cell growth

1990 • 152 citations

Characterization of the XRN1 gene encoding a 5'→3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells

1992 • 142 citations

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

1992 • 140 citations

Interferon, double-stranded RNA, and RNA degradation: activation of an endonuclease by (2'-5')An.

1979 • 140 citations

Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast.

1990 • 138 citations

Purification and characterization of an activity from Saccharomyces cerevisiae that catalyzes homologous pairing and strand exchange.

1987 • 132 citations

Fragments of the internal transcribed spacer 1 of pre-rRNA accumulate in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1

1991 • 128 citations

Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: Dependence on double-stranded RNA

1976 • 118 citations

Multiple determinants of eukaryotic mRNA stability.

1989 • 118 citations

Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region

1989 • 118 citations

kem mutations affect nuclear fusion in Saccharomyces cerevisiae.

1990 • 117 citations

Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities

1991 • 112 citations

An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity.

1993 • 112 citations

A novel phosphodiesterase from cultured tobacco cells

1976 • 105 citations

Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1.

1991 • 104 citations

In vitro deadenylation of mammalian mRNA by a HeLa cell 3′ exonuclease.

1991 • 102 citations

Properties of the exonuclease activity that degrades H4 histone mRNA.

1987 • 102 citations

Enzymic Synthesis, Characterisation and Nuclear‐Magnetic‐Resonance Spectra of pppA2′p5′A2′p5′A and Related Oligonucleotides: Comparison with Chemically Synthesised Material

1979 • 101 citations

Poly(A) Tail Shortening Is the Translation-Dependent Step in c-myc mRNA Degradation

1990 • 100 citations

Histone mRNA Degradation In Vivo: the First Detectable Step Occurs at or near the 3′ Terminus

1986 • 98 citations

Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA.

1992 • 98 citations

c-myc RNA degradation in growing and differentiating cells: possible alternate pathways.

1989 • 98 citations

Cloning and characterization of DST2, the gene for DNA strand transfer protein beta from Saccharomyces cerevisiae.

1991 • 95 citations

A 5′ → 3′ exoribonuclease of Saccharomyces cerevisiae: Size and novel substrate specificity

1987 • 92 citations

Detection in HeLa cell extracts of a 7-methyl guanosine specific enzyme activity that cleaves m7GpppNm

1975 • 89 citations

Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells.

1989 • 86 citations

Purification and analysis of murine 2-5A-dependent RNase.

1988 • 83 citations

Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component.

1989 • 82 citations

Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay.

1990 • 81 citations

rarmutations which increase artificial chromosome stability inSaccharomyces cerevisiaeidentify transcription and recombination proteins

1991 • 76 citations

Purification and properties of a nuclear exoribonuclease from Ehrlich ascites tumor cells.

1967 • 76 citations

Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes.

1990 • 75 citations

Messenger RNA turnover in eukaryotic cells.

1988 • 74 citations

A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substratesx

1991 • 70 citations

Enzyme cleaving the 5′‐terminal methylated blocked structure of messenger RNA

1976 • 70 citations

An exoribonuclease from saccharomyces cerevisiae: Effect of modifications of 5′ end groups on the hydrolysis of substrates to 5′ mononucleotides

1978 • 69 citations

DNA strand transfer protein beta from yeast mitotic cells differs from strand transfer protein alpha from meiotic cells.

1990 • 64 citations

mRNA-decapping enzyme from Saccharomyces cerevisiae: purification and unique specificity for long RNA chains.

1988 • 58 citations

Substrate specificity of the exonuclease activity that degrades H4 histone mRNA.

1987 • 58 citations

Mechanisms of antiviral action of interferon.

1983 • 56 citations

Specific endonucleolytic cleavage of IGF-II mRNAs

1991 • 52 citations

Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation.

1990 • 50 citations

Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus.

1986 • 48 citations

Double-Stranded RNA and Interferon Action

1987 • 47 citations

Recombination and RNA processing: a common strand?

1991 • 47 citations

Characterization of two murine (2′‐5′)(A)_n‐dependent endonucleases of different molecular mass

1989 • 46 citations

Characterization of the m7G(5')pppN-pyrophosphatase activity from HeLa cells.

1977 • 45 citations

Biological activities of phosphodiester linkage isomers of 2-5A.

1983 • 45 citations

2‘,5‘-Oligo(A)-activated endoribonuclease. Tissue distribution and characterization with a binding assay.

1981 • 44 citations

Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.

1985 • 44 citations

Configuration of β-globin messenger RNA in rabbit reticulocytes

1984 • 43 citations

A 5′ exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells

1993 • 39 citations

Nucleotide pyrophosphatase from potato tubers

1984 • 33 citations

An mRNA decapping enzyme from ribosomes of Saccharomyces cerevisiae

1980 • 32 citations

A 5′–3′ exoribonuclease of human placental nuclei: purification and substrate specificity

1987 • 32 citations

Novel activity of potato nucleotide pyrophosphatase

1976 • 30 citations

[14] Characterization of cap structures

1989 • 29 citations

An invitro system derived from friend erythroleukemia cells to study messenger RNA stability

1987 • 29 citations

Isolation and properties of a single-strand 5' .fwdarw. 3' exoribonuclease from Ehrlich ascites tumor cell nucleoli

1984 • 28 citations

5'-Modified agonist and antagonist (2'-5')(A)n analogs: synthesis and biological activity

1987 • 28 citations

Activation of 2-5A-dependent RNase by analogs of 2-5A (5'-O-triphosphoryladenylyl(2'—-5')adenylyl(2'—-5')adenosine ) using 2',5'-tetraadenylate (core)-cellulose.

1986 • 26 citations

Protection of mRNA against nucleases in cytoplasmic extracts of mouse sarcoma ascites cells

1993 • 22 citations

Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment.

1985 • 22 citations

Purification and properties of a novel nucleolar exoribonuclease capable of degrading both single-stranded and double-stranded RNA

1985 • 20 citations

Evidence for a 5′ → 3′ direction of hydrolysis by a 5′ mononucleotide-producing exoribonuclease from Saccharomyces cerevisiae

1979 • 16 citations

[67] RNase L, a (2′-5′)-oligoadenylate-dependent endoribonuclease: Assays and purification of the enzyme; cross-linking to a (2′-5′)-oligoadenylate derivative

1986 • 12 citations