Nuclear Import and Export Signals Enable Rapid Nucleocytoplasmic Shuttling of the Atypical Protein Kinase C λ

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1999 • 1,011 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin β-Dependent Nuclear Localization Signals

1999 • 384 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

Transport into and out of the cell nucleus

1998 • 332 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

1998 • 331 citations

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1998 • 331 citations

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

1996 • 326 citations

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2is regulated by phosphorylation

1998 • 270 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

1991 • 251 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62

1998 • 230 citations

The atypical protein kinase Cs

2000 • 217 citations

Inositides and the nucleus and inositides in the nucleus

1993 • 209 citations

Importin β Can Mediate the Nuclear Import of an Arginine-Rich Nuclear Localization Signal in the Absence of Importin α

1999 • 207 citations

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

1997 • 194 citations

Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis

1997 • 175 citations

Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I.

1996 • 167 citations

Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ

1998 • 165 citations

Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade

1997 • 164 citations

Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of Xenopus laevis Oocytes

1992 • 162 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor

1999 • 142 citations

Intrapeptide regulation of protein kinase C.

1994 • 139 citations

Phosphatidylinositol 3-Kinase-dependent Activation of Protein Kinase C-ζ in Bacterial Lipopolysaccharide-treated Human Monocytes

1997 • 139 citations

Differential Stimulation of PKC Phosphorylation of Potassium Channels by ZIP1 and ZIP2

1999 • 130 citations

Evidence That a Phosphatidylinositol 3,4,5-Trisphosphate-binding Protein Can Function in Nucleus

1999 • 130 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Rb binds c-Jun and activates transcription

1998 • 122 citations

Nucleolin Is a Protein Kinase C-ζ Substrate

1997 • 120 citations

Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis

1999 • 119 citations

Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ

1999 • 118 citations

Conventional PKC-α, Novel PKC-ε and PKC-θ, but Not Atypical PKC-λ Are MARCKS Kinases in Intact NIH 3T3 Fibroblasts

1997 • 111 citations

Alpha-thrombin stimulates nuclear diglyceride levels and differential nuclear localization of protein kinase C isozymes in IIC9 cells.

1992 • 110 citations

Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ɛ) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ

1999 • 110 citations

Increase in nuclear phosphatidylinositol 3‐kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC‐ζ translocation to the nucleus of NGF‐treated PC12 cells

1999 • 107 citations

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.

1992 • 104 citations

Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I.

1998 • 92 citations

A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells.

1994 • 90 citations

Transport pathways of macromolecules between the nucleus and the cytoplasm

1999 • 87 citations

Cleavage of ζPKC but Not λ/ιPKC by Caspase-3 during UV-induced Apoptosis

1999 • 87 citations

Identification of Heterogeneous Ribonucleoprotein A1 as a Novel Substrate for Protein Kinase C ζ

1995 • 85 citations

The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.

1992 • 74 citations

Activation of Protein Kinase C-ζ and Phosphatidylinositol 3′-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I

1998 • 69 citations

Okadaic Acid Activates Atypical Protein Kinase C (ζ/λ) in Rat and 3T3/L1 Adipocytes

1999 • 68 citations

Phospholipase C-δ1 Contains a Functional Nuclear Export Signal Sequence

1999 • 68 citations

Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.

1994 • 65 citations

Agonists Cause Nuclear Translocation of Phosphatidylinositol 3-Kinase γ

1999 • 64 citations

Nuclear import of protein kinase C occurs by a mechanism distinct from the mechanism used by proteins with a classical nuclear localization signal

1998 • 58 citations

Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-ζ isoform

1994 • 56 citations

Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: Association of atypical ?-PKC with the nuclear matrix

1997 • 50 citations

PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta.

1996 • 44 citations

Localization of non-conventional protein kinase C isoforms in bovine brain cell nuclei

1995 • 34 citations

Inhibitory Properties of the Regulatory Domains of Human Protein Kinase Cα and Mouse Protein Kinase Cε

1998 • 25 citations

Cell polarity: Scaffold proteins par excellence

2000 • 18 citations