Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Oncogenes and signal transduction

1991 • 2,816 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

1989 • 396 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Structure and polymorphism of human telomere-associated DNA

1990 • 382 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroups

1986 • 329 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Splicing with inverted order of exons occurs proximal to large introns.

1992 • 293 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

1990 • 244 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 183 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

A Conserved Alternative Splice in the von Recklinghausen Neurofibromatosis (NF1) Gene Produces Two Neurofibromin Isoforms, Both of Which Have GTPase-Activating Protein Activity

1993 • 159 citations

Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K ⁺ Channel Currents

1992 • 154 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.

1987 • 141 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Signal transduction through small GTPases—A tale of two GAPs

1992 • 137 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

Differential expression of two types of the neurofibromatosis type 1 (NF1) gene transcripts related to neuronal differentiation.

1991 • 119 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion

1992 • 101 citations

Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21.

1984 • 91 citations

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1992 • 76 citations

bcr genes and transcripts.

1988 • 74 citations

The hemopoietic stem cell antigen, CD34, is encoded by a gene located on chromosome 1.

1989 • 69 citations

Genetic counterselective procedure to isolate interspecific cell hybrids containing single human chromosomes: Construction of cell hybrids and recombinant DNA libraries specific for human chromosomes 3 and 4

1986 • 68 citations

In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase.

1993 • 63 citations

Expression of the CRE-BP1 transcriptional regulator binding to the cyclic AMP response element in central nervous system, regenerating liver, and human tumors.

1991 • 62 citations

Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints.

1987 • 62 citations

Nucleotide sequence analysis of human abl and bcr-abl cDNAs.

1989 • 56 citations

The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1

1992 • 54 citations

Random-primed cDNA synthesis facilitates the isolation of multiple 5'-cDNA ends by RACE

1991 • 52 citations

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

1992 • 43 citations

ABR, an active BCR-related gene

1989 • 39 citations

Nerve growth factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase C-gamma 1.

1992 • 35 citations

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence

1992 • 33 citations

Duplication of thebcrand gamma-glutamyl transpeptidase genes

1988 • 33 citations

Differential regulation in the avian song control circuit of an mRNA predicting a highly conserved protein related to protein kinase C and the bcr oncogene

1992 • 29 citations

New regional localisations for HAGH and PGP on human chromosome 16

1986 • 21 citations

Fine Mapping of Probes in the Adenomatous Polyposis Coli Region of Chromosome 5 by In Situ Hybridization

1991 • 17 citations

Assignment of the human CREB2 (CRE-BP1) gene to 2q32

1991 • 15 citations