Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Nearest neighbor pattern classification

1967 • 13,310 citations

Cancer Statistics, 2010

2010 • 12,557 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

The Epigenomics of Cancer

2007 • 4,239 citations

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

2009 • 3,957 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

2010 • 2,179 citations

Untitled

2003 • 1,901 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Randomized Controlled Trial of Azacitidine in Patients With the Myelodysplastic Syndrome: A Study of the Cancer and Leukemia Group B

2002 • 1,770 citations

Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

2005 • 1,467 citations

Decitabine improves patient outcomes in myelodysplastic syndromes

2006 • 1,450 citations

EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

2010 • 1,163 citations

CpG island methylator phenotype in cancer

2004 • 1,052 citations

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

2004 • 998 citations

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer

2007 • 549 citations

Gene-promoter hypermethylation as a biomarker in lung cancer

2004 • 522 citations

Sensitive Sequencing Method for KRAS Mutation Detection by Pyrosequencing

2005 • 492 citations

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

2000 • 462 citations

Molecular Classification and Correlates in Colorectal Cancer

2007 • 444 citations

Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis

2004 • 442 citations

DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes

2009 • 335 citations

CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 • 296 citations

Cigarette Smoking and Colorectal Cancer Risk by Molecularly Defined Subtypes

2010 • 285 citations

Association of Smoking, CpG Island Methylator Phenotype, and V600E BRAF Mutations in Colon Cancer

2006 • 266 citations

Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis

2011 • 263 citations

Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

2006 • 222 citations

Three DNA Methylation Epigenotypes in Human Colorectal Cancer

2009 • 216 citations

Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer

2011 • 205 citations

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

2007 • 200 citations

Mutational and Epigenetic Evidence for Independent Pathways for Lung Adenocarcinomas Arising in Smokers and Never Smokers

2006 • 161 citations

Exclusive mutation in epidermal growth factor receptor gene, HER‐2, and KRAS, and synchronous methylation of nonsmall cell lung cancer

2006 • 126 citations

Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma

2009 • 124 citations

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas

2008 • 120 citations

Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma

2007 • 105 citations

Examination of a CpG Island Methylator Phenotype and Implications of Methylation Profiles in Solid Tumors

2006 • 96 citations

Potential of 5-aza-2′-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer

2001 • 87 citations

EGFR point mutation in non‐small cell lung cancer is occasionally accompanied by a second mutation or amplification

2006 • 74 citations

Molecular Characterization of Chronic Obstructive Pulmonary Disease-Related Non-Small Cell Lung Cancer Through Aberrant Methylation and Alterations of EGFR Signaling

2009 • 71 citations

Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour

2011 • 60 citations

CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer

2008 • 57 citations

Characteristic methylation profile in CpG island methylator phenotype‐negative distal colorectal cancers

2010 • 35 citations

Prognosis of Myelodysplastic Syndromes

2010 • 28 citations